Antioxidant activity and hypoglycemic effect assessment of the leaves from Syzygium cumini (L. ) Skeels in Wistar rats
Acta sci., Health sci
;
43: e52931, Feb.11, 2021.
Artigo
em Inglês
| LILACS
| ID: biblio-1368486
ABSTRACT
Syzygiumcumini(L.) Skeels wasadaptedto the climatic conditionsandsoil typesin Brazil. Its fruits, leaves andinner barkare usedin folk medicinedue to their highantioxidant, anti-inflammatory, anticarcinogenicandantidiabeticactivities mainlyassociated with the presenceof phenolic compounds. It is estimated thatat least300million peopleworldwide developdiabetesand approximately 11million peopleare carriersof the disease in Brazil.The objectiveof this workwas to evaluate thein vitro antioxidant activity, as well as thehypoglycemic actionofhydroethanolic extract(HEE), the ethyl acetate(EAF) andhydromethanolic(HMF) fractions from leavesofS.cumini(L.) Skeels in rats. All assays werecarried out in three replications. Data wereexpressed as meanï±SDand significance was evaluated by ANOVAand Bonferronitest (p < 0.05). The results indicatea significant(p < 0.05) total phenolcontent (207 ± 2.3GAE mg g-1) andantioxidant activity(EC50=9.05±0.170 µg mL-1) for EAF. HEE and its fractions showed no significant (p > 0.05) actionto modulateglucosebytheOGTT assayinnondiabetic micecompared to control. Thus the use of the plant against diabetes in individuals is not proven.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Produtos Biológicos
/
Ratos Wistar
/
Syzygium
/
Hipoglicemiantes
/
Antioxidantes
Tipo de estudo:
Estudos de avaliação
Limite:
Animais
Idioma:
Inglês
Revista:
Acta sci., Health sci
Assunto da revista:
Medicina
/
Sa£de P£blica
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal de Sergipe/BR
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