In vivo protective effect of cinnamon aqueous extract in carbon tetrachloride-treated male albino rats
Acta sci., Health sci
;
43: e52826, Feb.11, 2021.
Artigo
em Inglês
| LILACS
| ID: biblio-1368744
ABSTRACT
The liver as an organ is important for the metabolism of drugs and toxins. However, it is not immune from environmental insults. Exposure of liver cells to carbon tetrachloride (CCl4) results in the generation of tricholoromethyl radicals, which induce liver toxicity. This study aims at investigating the ameliorative effect of the cinnamon aqueous extract (CAE) against CCl4-induced hepatotoxicity in male albino rats. Hepatotoxicity was induced in rats through the intraperitoneal administration of 0.5 mL kg-1body weight of CCl4. The analyses of the results obtained showed significant reduction in the levels of serum biochemical markers for 400 and 600 mg kg-1bw of CAE protected rats as compared with CCl4group. In addition, CAE administration reversed liver tissue damaged via increased antioxidants markers. Histopathological examination of CAE treatment on rats showed improved changes to the liver damage caused by CCl4 with no evidence of steatosis and inflammation. This result hence suggests that CAE has marked hepatoprotective and healing activities against CCl4-induced liver damage and could serve as a suitable candidate in drug discovery for the treatment of liver toxicity.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Tetracloreto de Carbono
/
Cinnamomum zeylanicum
/
Fígado
Limite:
Animais
Idioma:
Inglês
Revista:
Acta sci., Health sci
Assunto da revista:
Medicina
/
Sa£de P£blica
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Arábia Saudita
Instituição/País de afiliação:
King Abdulaziz University/SA
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