Immunomodulatory effects of Blaps rynchopetera extract
Acta cir. bras
;
37(2): e370205, 2022. tab, graf, ilus
Artigo
em Inglês
| LILACS, VETINDEX
| ID: biblio-1374067
ABSTRACT
Purpose:
To explore the potential immunomodulatory effects of total extract and different polar parts from Blaps rynchopetera Fairmaire.Methods:
Phagocytic activity was evaluated by neutral red assay, and the effect of the immune function was investigated by normal and immunocompromised mice models.Results:
In vitro, total extract, as well as chloroform, ethyl acetate, n-butanol and water fractions could individually enhance the phagocytic ability of mouse peritoneal macrophages; in addition, chloroform and ethyl acetate fractions had an increasing tendency when combined stimulation with lipopolysaccharide (LPS). In vivo, ethyl acetate fraction (EAF) could enhance the immune organ index, increase the serum hemolysin level and peripheral blood immune cells of immunocompromised mice, while for normal mice, the effect was inconspicuous.Conclusions:
Blaps rynchopetera extracts had noteworthy immunomodulatory effect, especially for individuals with immune disorders.Assuntos
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Besouros
/
Hospedeiro Imunocomprometido
/
Fatores Imunológicos
/
Medicina Tradicional Chinesa
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Ano de publicação:
2022
Tipo de documento:
Artigo
Instituição/País de afiliação:
Dali University/CN
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