Solid Phase Extraction and Simultaneous Chromatographic Quantification of some Non-steroidal Anti-inflammatory Drug Residues; an Application in Pharmaceutical Industrial Wastewater Effluent
Braz. J. Pharm. Sci. (Online)
;
58: e18691, 2022. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1374574
ABSTRACT
Abstract Two sensitive and selective methods were developed for the simultaneous determination of four commonly used non-steroidal anti-inflammatory drugs (NSAIDs), namely; paracetamol (PCM), diclofenac sodium (DCF), ibuprofen (IBP), and indomethacin (IND) in wastewater effluents. The first method used HPLC for the determination of the studied drugs using a mobile phase consisting of phosphate buffer (pH 3.0) and acetonitrile at a flow rate of 1 mL/min. in gradient elution mode and detection at 220 nm. The separation process was performed on BDS Hypersil Cyano column (250 x 4.6 mm, 5 µm). The second method was a TLC-densitometric one which was performed using n-Hexane ethyl acetate acetic acid in the ratio (63.50.5) as a developing system. The proposed chromatographic methods were successfully applied for the selective determination of the four studied drugs in simulated and real pharmaceutical wastewater samples after their solid-phase extraction
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Efluentes Industriais
/
Anti-Inflamatórios não Esteroides
/
Indústria Farmacêutica
/
Águas Residuárias
Idioma:
Inglês
Revista:
Braz. J. Pharm. Sci. (Online)
Assunto da revista:
Farmacologia
/
Teraputica
/
Toxicologia
Ano de publicação:
2022
Tipo de documento:
Artigo
País de afiliação:
Egito
/
Arábia Saudita
Instituição/País de afiliação:
Cairo University/EG
/
Future University/EG
/
Pharmaoverseas Company/EG
/
Prince Sattam Bin Abdul-Aziz University/SA
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