The translational challenge in Chagas disease drug development
Mem. Inst. Oswaldo Cruz
;
117: e200501, 2022. graf
Artigo
em Inglês
|
LILACS-Express
| LILACS
| ID: biblio-1375909
ABSTRACT
Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. There is an urgent need for safe, effective, and accessible new treatments since the currently approved drugs have serious limitations. Drug development for Chagas disease has historically been hampered by the complexity of the disease, critical knowledge gaps, and lack of coordinated R&D efforts. This review covers some of the translational challenges associated with the progression of new chemical entities from preclinical to clinical phases of development, and discusses how recent technological advances might allow the research community to answer key questions relevant to the disease and to overcome hurdles in R&D for Chagas disease.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2022
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
/
Suíça
Instituição/País de afiliação:
Drugs for Neglected Diseases initiative/CH
/
Universidade Federal de São Paulo/BR
/
Universidade de São Paulo/BR
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