Parasitological, serological and molecular diagnosis of acute and chronic Chagas disease: from field to laboratory
Mem. Inst. Oswaldo Cruz
;
117: e200444, 2022. tab, graf
Artigo
em Inglês
|
LILACS-Express
| LILACS
| ID: biblio-1375921
ABSTRACT
There is no consensus on the diagnostic algorithms for many scenarios of Trypanosoma cruzi infection, which hinders the establishment of governmental guidelines in endemic and non-endemic countries. In the acute phase, parasitological methods are currently employed, and standardised surrogate molecular tests are being introduced to provide higher sensitivity and less operator-dependence. In the chronic phase, IgG-based serological assays are currently used, but if a single assay does not reach the required accuracy, PAHO/WHO recommends at least two immunological tests with different technical principles. Specific algorithms are applied to diagnose congenital infection, screen blood and organ donors or conduct epidemiological surveys. Detecting Chagas disease reactivation in immunosuppressed individuals is an area of increasing interest. Due to its neglect, enhancing access to diagnosis of patients at risk of suffering T. cruzi infection should be a priority at national and regional levels.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Tipo de estudo:
Estudo diagnóstico
/
Guia de Prática Clínica
/
Pesquisa qualitativa
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2022
Tipo de documento:
Artigo
País de afiliação:
Argentina
/
Espanha
/
Suíça
Instituição/País de afiliação:
Barcelona Institute for Global Health/ES
/
Foundation for Innovative New Diagnostics/CH
/
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular Dr Hector Torres/AR
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