Update on the pathogenesis of vitiligo
An. bras. dermatol
;
97(4): 478-490, July-Aug. 2022. tab, graf
Artigo
em Inglês
|
LILACS-Express
| LILACS
| ID: biblio-1383607
ABSTRACT
Abstract Vitiligo is a complex disease whose pathogenesis results from the interaction of genetic components, metabolic factors linked to cellular oxidative stress, melanocyte adhesion to the epithelium, and immunity (innate and adaptive), which culminate in aggression against melanocytes. In vitiligo, melanocytes are more sensitive to oxidative damage, leading to the increased expression of proinflammatory proteins such as HSP70. The lower expression of epithelial adhesion molecules, such as DDR1 and E-cadherin, facilitates damage to melanocytes and exposure of antigens that favor autoimmunity. Activation of the type 1-IFN pathway perpetuates the direct action of CD8+ cells against melanocytes, facilitated by regulatory T-cell dysfunction. The identification of several genes involved in these processes sets the stage for disease development and maintenance. However, the relationship of vitiligo with environmental factors, psychological stress, comorbidities, and the elements that define individual susceptibility to the disease are a challenge to the integration of theories related to its pathogenesis.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
Idioma:
Inglês
Revista:
An. bras. dermatol
Assunto da revista:
Dermatologia
Ano de publicação:
2022
Tipo de documento:
Artigo
País de afiliação:
Brasil
/
Canadá
Instituição/País de afiliação:
Hospital Irmandade Santa Casa de Misericórdia de Curitiba/BR
/
Mcgill University/CA
/
Pontifícia Universidade Católica do Paraná/BR
/
Universidade Estadual Paulista/BR
/
Universidade Estadual do Oeste do Paraná/BR
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