Your browser doesn't support javascript.
loading
Tadalafil and Sildenafil illicit association: Stability- indicating HPLC method, photodegradation kinetic and toxicological studies
Pinto, Mayara Aramburú; Nicorena, Karine Favero; Machado, Michel Mansur; Oliveira, Luís Flávio Souza de; Paim, Clésio Soldateli; Silva, Fabiana Ernestina Barcellos da; Malesuik, Marcelo Donadel.
  • Pinto, Mayara Aramburú; Federal University of Pampa. Post Graduate Program in Pharmaceutical Sciences. Uruguaiana. BR
  • Nicorena, Karine Favero; Federal University of Pampa. School of Pharmacy. Uruguaiana. BR
  • Machado, Michel Mansur; Federal University of Pampa. Post Graduate Program in Pharmaceutical Sciences. Uruguaiana. BR
  • Oliveira, Luís Flávio Souza de; Federal University of Pampa. Post Graduate Program in Pharmaceutical Sciences. Uruguaiana. BR
  • Paim, Clésio Soldateli; Federal University of Pampa. Post Graduate Program in Pharmaceutical Sciences. Uruguaiana. BR
  • Silva, Fabiana Ernestina Barcellos da; Federal University of Pampa. Post Graduate Program in Pharmaceutical Sciences. Uruguaiana. BR
  • Malesuik, Marcelo Donadel; Federal University of Pampa. Post Graduate Program in Pharmaceutical Sciences. Uruguaiana. BR
Braz. J. Pharm. Sci. (Online) ; 58: e19491, 2022. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1383957
ABSTRACT
Abstract The illicit market of counterfeit medicines containing sildenafil and tadalafil has been causing serious public health problems. Thus, further studies on this illicit association are needed. A stability-indicating HPLC method was developed for simultaneous determination of tadalafil (TAD) and sildenafil (SIL) using a C18 column (250 x 4.6 mm, 5 µm). Detection was achieved at 284 nm, for TAD, and 292 nm, for SIL. The method was considered to be specific, linear, precise, accurate, robust, and sensitive. In the photodegradation kinetic studies, the drugs showed a first-order reaction rate when isolated, and zero-order when associated. Toxicological assays demonstrated that the photodegraded drugs decreased cell viability in compared to non- degraded drugs, suggesting cytotoxic activity. Additional, mutagenic activity was not observed under the tested conditions. Photodegraded drugs, in association, depicted DNA damage index, suggesting genotoxic effects. The obtained results will be able to support the forensic intelligence laboratories, as well as to alert the population about the risk inherent to consuming counterfeit products.
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Cromatografia Líquida de Alta Pressão / Fotodegradação / Citrato de Sildenafila / Tadalafila Tipo de estudo: Fatores de risco Idioma: Inglês Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2022 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Federal University of Pampa/BR

Similares

MEDLINE

...
LILACS

LIS


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Cromatografia Líquida de Alta Pressão / Fotodegradação / Citrato de Sildenafila / Tadalafila Tipo de estudo: Fatores de risco Idioma: Inglês Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2022 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Federal University of Pampa/BR