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C-reactive protein to lymphocyte count ratio is a promising novel marker in hepatitis C infection: the clear hep-c study
Demirkol, Muhammed Emin; Aktas, Gulali; Bilgin, Satilmiş; Kahveci, Gizem; Kurtkulagi, Ozge; Atak, Burcin Meryem; Duman, Tuba Taslamacioglu.
  • Demirkol, Muhammed Emin; Abant Izzet Baysal University Hospital. Department of Internal Medicine. Bolu. TR
  • Aktas, Gulali; Abant Izzet Baysal University Hospital. Department of Internal Medicine. Bolu. TR
  • Bilgin, Satilmiş; Abant Izzet Baysal University Hospital. Department of Internal Medicine. Bolu. TR
  • Kahveci, Gizem; Abant Izzet Baysal University Hospital. Department of Internal Medicine. Bolu. TR
  • Kurtkulagi, Ozge; Abant Izzet Baysal University Hospital. Department of Internal Medicine. Bolu. TR
  • Atak, Burcin Meryem; Abant Izzet Baysal University Hospital. Department of Internal Medicine. Bolu. TR
  • Duman, Tuba Taslamacioglu; Abant Izzet Baysal University Hospital. Department of Internal Medicine. Bolu. TR
Rev. Assoc. Med. Bras. (1992) ; 68(6): 838-841, June 2022. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1387150
ABSTRACT
SUMMARY

OBJECTIVE:

Chronic hepatitis C (CHC) is one of the most important health problems affecting the significant rate of world population and it may lead to cirrhosis and hepatocellular carcinoma. C-reactive protein to lymphocyte count ratio (CLR) is used in estimating inflammatory burden. Therefore, this study aimed to compare CLR values between CHC patients and healthy controls and between CHC patients with and without fibrosis.

METHODS:

Patients with CHC infection who visited outpatient and inpatient internal medicine clinics of our institution between January 2021 and December 2021 were enrolled to this retrospective study. CLR of the patients with CHC and healthy controls were compared. We further compared CLR of CHC patients with and without fibrosis.

RESULTS:

Median CLR of CHC and control subjects was 2.61 (5.13%) and 0.31 (0.37%), respectively. CLR of the CHC group was significantly increased compared to the CLR of the controls (p<0.001). There was a significant positive correlation between CLR and APRI score (r=0.15, p=0.04). The sensitivity and specificity of CLR in determining CHC above 0.58% level were 84% and 82%, respectively (AUC 0.884, p<0.001, 95%CI 0.84-0.93). In subgroup analysis, CLR was 3.97 (6.6%) for CHC patients with fibrosis and 1.7 (4.4%) for CHC subjects without fibrosis (p=0.001).

CONCLUSION:

Increased CLR in patients with CHC may be an alarming finding of liver fibrosis, as CLR is associated with both CHC and hepatic fibrosis.


Texto completo: DisponíveL Índice: LILACS (Américas) Tipo de estudo: Estudo observacional / Fatores de risco Idioma: Inglês Revista: Rev. Assoc. Med. Bras. (1992) Ano de publicação: 2022 Tipo de documento: Artigo País de afiliação: Turquia Instituição/País de afiliação: Abant Izzet Baysal University Hospital/TR

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Texto completo: DisponíveL Índice: LILACS (Américas) Tipo de estudo: Estudo observacional / Fatores de risco Idioma: Inglês Revista: Rev. Assoc. Med. Bras. (1992) Ano de publicação: 2022 Tipo de documento: Artigo País de afiliação: Turquia Instituição/País de afiliação: Abant Izzet Baysal University Hospital/TR