Rol de la microbiota intestinal en el desarrollo del hígado graso no alcohólico / The role of intestinal microbiota in the development of non-alcoholic fatty liver disease
Rev. méd. Chile
;
149(4): 570-579, abr. 2021. ilus, tab
Artigo
em Espanhol
| LILACS
| ID: biblio-1389496
ABSTRACT
Non-alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of hepatic pathologies ranging from simple steatosis (SS) to hepatocellular carcinoma. Intestinal microbiota (IM) is composed of trillions of microorganisms existing in the gut. It has 150 times more genes than the host. Changes in the composition and function of the IM are associated with different diseases, including NAFLD. In this condition, IM could have a pathogenic role through different mechanisms such as energy salvaging from food, an inflammatory stimulus, a modulation of the innate immune system, regulation of bile acid turnover, alteration of choline metabolism and increasing endogenous ethanol levels. This review is an update on the role of the intestinal microbiota in NAFLD and the possible mechanisms involved.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Hepatopatia Gordurosa não Alcoólica
/
Microbioma Gastrointestinal
Limite:
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Chile
Instituição/País de afiliação:
Pontificia Universidad Católica de Chile/CL
/
Universidad San Sebastián/CL
/
Universidad de Chile/CL
Similares
MEDLINE
...
LILACS
LIS