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Graft versus host disease-related eosinophilic fasciitis: cohort description and literature review
Calleja, Cristina Hidalgo; Hidalgo, Daniel Martín; Curto, Concepción Román; López, Lourdes Vázquez; López, Estefanía Pérez; Calvo, Mónica Cabrero; López, Ana África Martín; Barrigón, María Dolores Caballero; Lopez-Corral, Lucía.
  • Calleja, Cristina Hidalgo; Complejo Asistencial Universitario de Salamanca-IBSAL. Rheumatology Department. Salamanca. ES
  • Hidalgo, Daniel Martín; Hospital Universitario Río Hortega. Family and Community Medicine Training Programme. Valladolid. ES
  • Curto, Concepción Román; Complejo Asistencial Universitario de Salamanca-IBSAL. Dermatology Department. Salamanca. ES
  • López, Lourdes Vázquez; University Hospital of Salamanca. CIBERONC and Cancer Research Institute of Salamanca-IBMCC. Haematology Department. Salamanca. ES
  • López, Estefanía Pérez; University Hospital of Salamanca. CIBERONC and Cancer Research Institute of Salamanca-IBMCC. Haematology Department. Salamanca. ES
  • Calvo, Mónica Cabrero; University Hospital of Salamanca. CIBERONC and Cancer Research Institute of Salamanca-IBMCC. Haematology Department. Salamanca. ES
  • López, Ana África Martín; University Hospital of Salamanca. CIBERONC and Cancer Research Institute of Salamanca-IBMCC. Haematology Department. Salamanca. ES
  • Barrigón, María Dolores Caballero; University Hospital of Salamanca. CIBERONC and Cancer Research Institute of Salamanca-IBMCC. Haematology Department. Salamanca. ES
  • Lopez-Corral, Lucía; University Hospital of Salamanca. CIBERONC and Cancer Research Institute of Salamanca-IBMCC. Haematology Department. Salamanca. ES
Adv Rheumatol ; 62: 33, 2022. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1393816
ABSTRACT
Abstract

Background:

Chronic graft versus host disease (cGVHD) simulating eosinophilic fasciitis (EF) is an underdiagnosed and challenging complication due to the lack of knowledge about its pathogenesis, refractoriness to traditional immunosuppressive agents and their negative impact on the physical function and quality of life. The aim of this study is to describe the clinical-biological characteristics and response to treatment of a case series and to provide a comprehensive literature review on cGVHD related EF involvement.

Methods:

Prospective observational study to describe the clinical and diagnostic evaluation characteristics of patients with EF-like follow-up as part of our multidisciplinary cGVHD consultations. In addition, the literature on joint and/or fascial musculoskeletal manifestations due to cGVHD was comprehensively reviewed.

Results:

118 patients were evaluated in multidisciplinary cGVHD consultations, 39 of whom (33%) developed fasciitis. Notably, 11 patients had isolated joint contractures without sclerotic skin. After a median of three lines of treatment, the vast majority of patients achieved some degree of response. 94 potentially eligible articles were identified by the search strategy, with 17 of them, the majority isolated case reports, making the final selection. The validated staging scales used for the assessment were the Joint and Fascial Score and the Photographic Range of Motion.

Conclusion:

Fascial/articular involvement needs to be recognized and evaluated early. To our knowledge, our cohort is the second largest series to have been reported. Literature addressing fascial/joints complications related to cGVHD is scarce. The search for new biomarkers, the use of advanced imaging techniques and multidisciplinary approach may help improve the prognosis of patients with cGVHD.


Texto completo: DisponíveL Índice: LILACS (Américas) Tipo de estudo: Estudo observacional / Estudo prognóstico / Revisões Sistemáticas Avaliadas Idioma: Inglês Revista: Adv Rheumatol Assunto da revista: Artrite / Reumatologia Ano de publicação: 2022 Tipo de documento: Artigo / Documento de projeto País de afiliação: Espanha Instituição/País de afiliação: Complejo Asistencial Universitario de Salamanca-IBSAL/ES / Hospital Universitario Río Hortega/ES / University Hospital of Salamanca/ES

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Texto completo: DisponíveL Índice: LILACS (Américas) Tipo de estudo: Estudo observacional / Estudo prognóstico / Revisões Sistemáticas Avaliadas Idioma: Inglês Revista: Adv Rheumatol Assunto da revista: Artrite / Reumatologia Ano de publicação: 2022 Tipo de documento: Artigo / Documento de projeto País de afiliação: Espanha Instituição/País de afiliação: Complejo Asistencial Universitario de Salamanca-IBSAL/ES / Hospital Universitario Río Hortega/ES / University Hospital of Salamanca/ES