Infliximab for anoperineal lesions in Crohn's disease: remission appears to be based on rapid combination therapy at high doses
J. coloproctol. (Rio J., Impr.)
;
42(2): 126-130, Apr.-June 2022. tab, ilus
Artigo
em Inglês
| LILACS
| ID: biblio-1394412
ABSTRACT
Study Aim:
The aim of the present study was to compare in real life the characteristics of treatment with infliximab according to the presence or absence of anoperineal involvement in Crohn's disease.Methods:
We performed a single-center, prospective, non-interventional study, on patients with Crohn's disease in remission who had been treated with infliximab for at least 1 year. Patients with poor treatment compliance, on antibiotics, or those with a stoma were excluded.Results:
We included 52 patients in this study 34 with anoperineal lesions with or without luminal lesions, and 18 with luminal lesions only. Patients with anoperineal lesions were more likely to have undergone surgery (70.6% versus 38.9%, p = 0.027), had a shorter median time to infliximab treatment initiation (0.5 versus 5.5 years, p = 0.005), a higher mean dose of infliximab (6.6 versus 5.1 mg/kg, p = 0.015), and were more likely to receive combination treatments including infliximab (52.9% versus 11.1%, p = 0.008) than patients with luminal involvement only. Conclusions In our study, infliximab treatment was initiated more quickly, at higher doses, and more in combination therapy for anoperineal Crohn's disease than for luminal damage alone. Additional studies are required to confirm this finding and to assess the tolerance of this treatment throughout patient management. (AU)
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Canal Anal
/
Períneo
/
Terapia Combinada
/
Infliximab
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
J. coloproctol. (Rio J., Impr.)
Assunto da revista:
Cirurgia
/
Doenas Retais
/
Doenas do Colo
/
Gastroenterologia
/
Cirurgia
Ano de publicação:
2022
Tipo de documento:
Artigo
País de afiliação:
França
Instituição/País de afiliação:
Assistance Publique-Hôpitaux de Paris/FR
/
Groupe Hospitalier Paris Saint-Joseph/FR
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