Effects of Bacillus firmus e volumine ex muris cellulae 6x on cytolytic activity of natural killer cells in vitro
Int. j. high dilution res
; 20(2/3): 34-43, June 4, 2021.
Article
em En
| LILACS, HomeoIndex
| ID: biblio-1396358
Biblioteca responsável:
BR926.1
ABSTRACT
Natural killer (NK) cells are among the first in defense of the innate immune system by eliminating a variety of abnormal or stressed cells such as cancer cells or virus-infected cells. Individuals who exhibit low cytolytic NK cell activity are believed to be at higher risk of viral infection, tumorigenesis, and various other diseases of the immune system. Therefore, restoration of impaired NK cell function might be an essential step in immunostimulatory therapy of immunocompromised patients. Bacillus firmus is a non-pathogenic gram-positive bacterium of the environment, which possesses various immunomodulatory properties in vitro and in vivo. This retrospective study reports on the effect of B. firmus on the activity of NK cells in vitro. Basal cytolytic NK cell activity against tumor cells among peripheral blood mononuclear cells (PBMCs) of routine patients was determined in a standardized NK cell cytotoxicity assay. The impact of cultivation of PBMCs with B. firmus preparation Bacillus firmus e volumine ex muris cellulae (Bacillus firmus (evc)) 6x on tumor cell killing by NK cells was monitored in relation to basal NK cell activity. This study showed that stimulation of PBMCs with Bacillus firmus (evc) 6x in vitro led to a significant increase in NK cell function. Substantial improvement in cytolytic NK cell activity (more than 1.3-fold of basal activity) was much more pronounced for patients with compromised NK cell function. Due to its immunostimulatory mode of action, Bacillus firmus (evc) may be of particular importance in therapy of patients with NK cell deficiency.
Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Células Matadoras Naturais
/
Células K562
/
Bacillus firmus
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Int. j. high dilution res
Assunto da revista:
HOMEOPATIA
/
Terapias Complementares
Ano de publicação:
2021
Tipo de documento:
Article