Performance of the allometric power model in scaling from adult to paediatric antiretroviral dose in children at a Referral Hospital in Windhoek, Namibia
African Health Sciences
;
22(3): 436-441, 2022-10-26. Figures, Tables
Artigo
em Inglês
| AIM
| ID: biblio-1401445
ABSTRACT
Background:
World Health Organization (WHO) advocates use of weight bands in antiretroviral therapy (ART) guidelines. Allometric scaling could be a more reliable method because it uses a non-linear approach in relating dose to body weight. This study evaluates performance of the allometric ¾ power model in comparison to WHO weight band method in children receiving ART.Methods:
Records of children receiving (ABC/3TC) + DTG were reviewed. Paediatric ABC/3TC dose was calculated from the adult dose using the allometric ¾ power model and compared to WHO weight band dose.Results:
WHO weight band strategy grouped 50.6% of the children in the 25 kg category and therefore received the adult dose of ABC/3TC (600 mg/300 mg); only 1.1% received this dose with allometric scaling. Mean dose (3.8 tablets) for the WHO weight band dosing method was found to be significantly higher (p<0.0001) than for allometric scaling (1.5 tablets).Conclusions:
WHO weight bands may result in the 25 kg weight category receiving a much higher dose leading to ADRs. Using allometric scaling, we recommend a weight band strategy that could improve paediatric ABC/3TC dosing
Texto completo:
DisponíveL
Índice:
AIM (África)
Assunto principal:
Peso Corporal
/
Terapia Antirretroviral de Alta Atividade
/
Dosagem
/
Análise de Escalonamento Multidimensional
Tipo de estudo:
Guia de Prática Clínica
Idioma:
Inglês
Revista:
African Health Sciences
Ano de publicação:
2022
Tipo de documento:
Artigo
Instituição/País de afiliação:
School of Pharmacy, Faculty of Health Sciences & Veterinary Medicine, University of Namibia/NA
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