Ivermectin treatment response in two rural villages with a high prevalence of onchocerciasis and epilepsy, Mahenge Tanzania
African Health Sciences
;
22(3): 607-616, 2022-10-26. Figures, Tables
Artigo
em Inglês
| AIM
| ID: biblio-1401819
ABSTRACT
Background:
Despite 20 years of ivermectin mass distribution in the Mahenge area, Tanzania, the prevalence of onchocerciasis and epilepsy has remained high in rural villages.Objectives:
We investigated the efficacy of ivermectin in reducing Onchocerca volvulus microfilariae and predictors for parasitic load following ivermectin treatment in persons with (PWE) and without epilepsy (PWOE).Methods:
Between April and September 2019, 50 PWE and 160 randomly selected PWOE from Msogezi and Mdindo villages participated in a follow-up study. Skin snips were obtained pre (baseline) and three months post-ivermectin treatment.Results:
The overall prevalence of O. volvulus positive skin snips at baseline was 49% (103/210), with no significant difference between PWE (58.0%) and PWOE (46.3%); p=0.197. The overall mean micro filarial density was significantly higher at baseline 1.45(95%CI0.98-2.04)) than three-month post-ivermectin treatment (0.23(95%CI0.11-0.37), p<0.001. Three months after ivermectin, the micro filarial density had decreased by ≥80% in 54 (81.8%, 95%CI 72.3-91.4) of the 66 individuals with positive skin snips at baseline. High micro filarial density at baseline was the only significant predictor associated with higher micro filarial density in the post-ivermectin skin snips.Conclusion:
Our study reports a decrease in micro filarial density following ivermectin treatment in most individuals. Optimizing ivermectin coverage will address the ongoing onchocerciasis transmission in Mahenge
Texto completo:
DisponíveL
Índice:
AIM (África)
Assunto principal:
Oncocercose
/
Terapêutica
/
Ivermectina
/
Epilepsia
Tipo de estudo:
Estudo observacional
/
Estudo de prevalência
/
Estudo prognóstico
/
Fatores de risco
País/Região como assunto:
África
Idioma:
Inglês
Revista:
African Health Sciences
Ano de publicação:
2022
Tipo de documento:
Artigo
Instituição/País de afiliação:
Global Health Institute, University of Antwerp, Antwerp, Belgium/BE
/
National Institute for Medical Research, Tanga Research Centre, Tanga, Tanzania/TZ
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