Identification Des Nouveaux Progrès Sur Les Molécules Dérivées Du Pyrazole Comme AgentsAntimicrobiens Et Antifongiques
West Afr. j. med
;
39(11): 1217-1244, 2022. tales, figures
Artigo
em Inglês
| AIM
| ID: biblio-1411031
ABSTRACT
Microbial infections remain a worldwide leading cause of death,despite the evolution of a large number of new antibiotics everyyear. Currently, several bacteria have developed resistanceagainst antibiotics drugs which remain a major issue inantibiotics drug discovery. This review provides detailedinformation about antimicrobial and antifungal agent synthesisbelonging to the pyrazoles scaffold. We reassemble the resultsobtained from several studies to characterize the importance ofheteroatom nuclei in many synthetic products. Additionally,several compounds based on pyrazole derivatives such asbenzimidazole, benzothiazole, indole, acridine, oxadiazole,imidazole, isoxazole, pyrazole, triazole, quinoline and quinazolineincluding other pyrazole containing drugs such as pyridazine,pyridine and pyrimidine are highlighted. Furthermore, you willfind in this review 134 best promise structures collected fromrecent studies, relating the pyrazoles structures to the relevantbiological activities, in particular, antimicrobial and antifungalone.
Texto completo:
DisponíveL
Índice:
AIM (África)
Assunto principal:
Resistência Microbiana a Medicamentos
/
Nitrogênio
Limite:
Humanos
Idioma:
Inglês
Revista:
West Afr. j. med
Ano de publicação:
2022
Tipo de documento:
Artigo
Instituição/País de afiliação:
Organic and Polymer Chemistry Team (ECOP).Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco+MA
/
Department of Biomedical Engine eringMedical Physiology, Higher School of Technical Education of Rabat, Mohammed V University in Rabat,/MA
/
Laboratory of Pharmacology and Toxicology, Bio Pharmaceutical and Toxicological Analysis Research Team, Faculty of Medicineand Pharmacy, Mohammed V University in Rabat, BP 620/MA
/
Laboratory of Therapeutic Chemistry, Faculty ofMedicine and Pharmacy, Mohammed V University in Rabat , BP 6203/MA
/
²Laboratory of Therapeutic Chemistry, Faculty ofMedicine and Pharmacy, Mohammed V University in Rabat , BP 6203/MA
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