A Potential SARS-CoV-2 Variant of Interest (VOI) Harboring Mutation E484K in the Spike Protein Was Identified within Lineage B 1 1 33 Circulating in Brazil
Viruses
;
13(5): 1-20, 2021.
Artigo
em Inglês
| LILACS, CONASS, ColecionaSUS, SES-SP, SESSP-IALPROD, SES-SP
| ID: biblio-1416914
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Brazil was dominated by two lineages designated as B.1.1.28 and B.1.1.33. The two SARS-CoV-2 variants harboring mutations at the receptor-binding domain of the Spike (S) protein, designated as lineages P.1 and P.2, evolved from lineage B.1.1.28 and are rapidly spreading in Brazil. Lineage P.1 is considered a Variant of Concern (VOC) because of the presence of multiple mutations in the S protein (including K417T, E484K, N501Y), while lineage P.2 only harbors mutation SE484K and is considered a Variant of Interest (VOI). On the other hand, epidemiologically relevant B.1.1.33 deriving lineages have not been described so far. Here we report the identification of a new SARS-CoV-2 VOI within lineage B.1.1.33 that also harbors mutation SE484K and was detected in Brazil between November 2020 and February 2021. This VOI displayed four non-synonymous lineage-defining mutations (NSP3A1711V, NSP6F36L, SE484K, and NS7bE33A) and was designated as lineage N.9. The VOI N.9 probably emerged in August 2020 and has spread across different Brazilian states from the Southeast, South, North, and Northeast regions.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Proteínas
/
SARS-CoV-2
/
Mutação
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Viruses
Ano de publicação:
2021
Tipo de documento:
Artigo
Instituição/País de afiliação:
Fiocruz COVID-19 Genomic Surveillance Network, Fiocruz/BR
/
Fundação de Vigilância em Saúde do Amazonas/BR
/
Instituto Adolfo Lutz (IAL)/BR
/
Laboratório Central de Saúde Pública do Amazonas/BR
/
Laboratório Central de Saúde Pública do Estado da Paraíba (LACEN-PB)/BR
/
Laboratório Central de Saúde Pública do Estado de Minas Gerais (LACEN-MG)/BR
/
Laboratório Central de Saúde Pública do Estado de Santa Catarina (LACEN-SC)/BR
/
Laboratório Central de Saúde Pública do Estado do Alagoas (LACEN-AL)/BR
/
Laboratório Central de Saúde Pública do Estado do Espírito Santo (LACEN-ES)/BR
/
Laboratório Central de Saúde Pública do Estado do Maranhão (LACEN-MA)/BR
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