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Metabolomic profiling and antidiabetic potential of Rumex vesicarius seed extract in high-fat diet and streptozotocin-induced diabeticrat
Rahman, Anisur; Ibrahim, Mohammad; Siddiqui, Javed Inam; Ansari, Shafeeque Ahmed; Ahmad, Sayeed.
Afiliação
  • Rahman, Anisur; Jamia Millia Islamia. Department of Biotechnology. New Delhi. IN
  • Ibrahim, Mohammad; Jamia Hamdard. School of Pharmaceutical Education and Research. Bioactive Natural Product Laboratories. New Delhi. IN
  • Siddiqui, Javed Inam; Central Institutes for Research in Unani Medicine. Department of IlmulAdvia (Pharmacology). Hyderabad. IN
  • Ansari, Shafeeque Ahmed; Jamia Millia Islamia. Department of Biotechnology. New Delhi. IN
  • Ahmad, Sayeed; Jamia Hamdard. School of Pharmaceutical Education and Research. Bioactive Natural Product Laboratories. New Delhi. IN
Braz. J. Pharm. Sci. (Online) ; 58: e21032, 2022. tab, graf
Article em En | LILACS-Express | LILACS | ID: biblio-1420417
Biblioteca responsável: BR1.1
ABSTRACT
Abstract Rumex vesicarius hasbeen extensively used for the management of diabetes in the traditional system of medicine. The current study was designed to investigate antidiabetic and antihyperlipidemic effects of R.vesicarius and also to explore metabolomic profiling using UPLC-QTOF-MS. The effect of extracts was observed by checking the biochemical and histopathological parameters in diabetic rats. The results had shown a significant dose- dependent inhibition potential of aqueous extract of R. vesicarius seed against α-amylase and α-glucosidase along with significant inhibition in DPPH free-radical scavenging activity. Oral administration of R. vesicarius to diabetic rats significantly ( p< 0.05) ameliorated blood glucose level. It also improved the function of the liver and kidney as well as ameliorated dyslipidemia in diabetic rats. Histopathological examination of the treatment groups reversed the damage of the pancreas, liver, and kidney tissues confirming the antidiabetic efficacy of R. vesicarius. UPLC- QTOF-MS analysis of the extract revealed a total of 42 bioactive compounds, which might contribute to the antidiabetic activity. Based on our findings, we can conclude that R. vesicarius might be a promising candidate for the management of diabetes.
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Texto completo: 1 Índice: LILACS Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Índice: LILACS Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2022 Tipo de documento: Article