Serum long-noncoding RNA H19 and beta-catenin as biomarkers for early diagnosis of colorectal cancer in egyptian patients: a case control study
J. coloproctol. (Rio J., Impr.)
; 42(3): 251-258, July-Sept. 2022. tab, graf
Article
em En
| LILACS
| ID: biblio-1421978
Biblioteca responsável:
BR545.3
ABSTRACT
Colorectal cancer (CRC) is the third most prevalent cancer and the second most common cause of cancer death; however, its early detection can improve the survival. Colonic polyps are considered one of the CRC's major risk factors. Throughout many biological processes and malignancies, the non-coding RNAs have essential functions. Certain long noncoding RNAs (lncRNAs), including H19, were supposed to be CRC possible biomarkers. Also, H19 has been reported to play a role in regulating the activity of beta-catenin, a protein that regulates cell-to-cell adhesion, as well as gene transcription. The current work aimed to investigate the potential significance of LncRNA H19 relative serum expression level by quantitative polymerase chain reaction (q-PCR) and beta-catenin by enzyme-linked immunosorbent assay (ELISA) as noninvasive biomarkers to discriminate between colorectal cancer and colonic polyps. The statistical analysis of the studied factors revealed that the serum expression of H19 and beta-catenin in cancer cases were substantially greater than colonic polyp cases and normal control. Conclusion:
The relative expressions of H19 and beta-catenin in the serum can significantly discriminate patients with CRC from those with polyp and normal controls, which could help when screening for CRC. (AU)Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Biomarcadores Tumorais
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Beta Catenina
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RNA Longo não Codificante
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Risk_factors_studies
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Screening_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
J. coloproctol. (Rio J., Impr.)
Assunto da revista:
Cirurgia
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Doenas Retais
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Doenas do Colo
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GASTROENTEROLOGIA
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Cirurgia
Ano de publicação:
2022
Tipo de documento:
Article