The effectiveness of insulin therapy in the functional and morphological recovery of leydig cells in rats submitted to Diabetes mellitus
Biosci. j. (Online)
;
39: e39033, 2023. ilus, tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1428168
ABSTRACT
The effects of systemic insulin administration at different concentrations on the testicular tissue of diabetic adult rats, induced by streptozotocin, are evaluated by the morphological analysis of spermatogenic process. Twenty-four adult male rats were divided into 1) Control Group: they received citrate buffer, by intraperitoneal injection; 2) Diabetic Group: induced by intraperitoneal injection of streptozotocin (60 mg. kg-1 of body weight); 3) Insulin 50%: induced diabetes treated with half of standard dosage of insulin; 4) Insulin 100%: induced diabetes treated with standard dose of insulin. After eight weeks, animals were weighted and anesthetized; testicles were removed and processed in resin. Body and testicular weight of diabetic rats decreased when compared to that of control. Parameters increased with insulin therapy. Testosterone levels were low in diabetic animals but rates recovered after insulin therapy. Nuclear diameter and volume of Leydig cells decreased in diabetic rats although they significantly increased after insulin therapy. Results showed that the administration of insulin in diabetic rats promoted a protective effect of testicular parenchyma, enhancing efficient recovery on testosterone levels and increase in daily sperm production.
C - Todos os direitos reservados
Assuntos
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Túbulos Seminíferos
/
Testículo
/
Convulsoterapia
/
Diabetes Mellitus
/
Células Intersticiais do Testículo
Idioma:
Inglês
Revista:
Biosci. j. (Online)
Assunto da revista:
Agricultura
/
Disciplinas das Cincias Biol¢gicas
/
Pesquisa Interdisciplinar
Ano de publicação:
2023
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal Rural de Pernambuco/BR
/
Universidade Federal de Pernambuco/BR
/
Universidade Federal do Paraná/BR
Similares
MEDLINE
...
LILACS
LIS