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Pediatric chronic myeloid leukemia in myeloid blast crisis
Dey, Biswajit; Dutta, Anirban.
  • Dey, Biswajit; North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences. Department of Pathology. Shillong. IN
  • Dutta, Anirban; University of Hawaii John A. Burns. School of Medicine. Department of Pediatrics. Honolulu. US
Autops. Case Rep ; 13: e2023426, 2023. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1429897
ABSTRACT
ABSTRACT Chronic myeloid leukemia (CML) accounts for 2-3% of childhood leukemias. About 5% of cases present in a blastic phase of CML which clinically and morphologically mimics more common acute leukemias of childhood. We report a case of a 3-year-old male who presented with gradual onset swelling of the abdomen and extremities along with generalized weakness. Examination revealed massive splenomegaly, pallor, and pedal edema. Initial workup showed anemia, thrombocytopenia, and leukocytosis (120,000/uL) with a blast percentage of 35%. Blasts were positive for CD13, CD33, CD117, CD34 and HLA-DR, and stained negative for Myeloperoxidase and Periodic Acid Schiff. Fluorescence in situ hybridization was positive for b3a2/e14a2 junction BCR-ABL1 transcript and negative for RUNX1-RUNX1T1/t(8;21), clinching the diagnosis of CML in myeloid blast crisis. The patient expired within 17 days of diagnosis and initiation of therapy.


Texto completo: DisponíveL Índice: LILACS (Américas) Idioma: Inglês Revista: Autops. Case Rep Assunto da revista: Anatomia / Patologia Cl¡nica / Patologia Legal Ano de publicação: 2023 Tipo de documento: Artigo País de afiliação: Índia / Estados Unidos Instituição/País de afiliação: North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences/IN / University of Hawaii John A. Burns/US

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Texto completo: DisponíveL Índice: LILACS (Américas) Idioma: Inglês Revista: Autops. Case Rep Assunto da revista: Anatomia / Patologia Cl¡nica / Patologia Legal Ano de publicação: 2023 Tipo de documento: Artigo País de afiliação: Índia / Estados Unidos Instituição/País de afiliação: North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences/IN / University of Hawaii John A. Burns/US