Anticonvulsant Activity of Carissa carandas Linn. Root Extract in Experimental Mice
Trop. j. pharm. res. (Online)
;
8(2): 117-125, 2009. tables
Artigo
em Inglês
| AIM
| ID: biblio-1434339
ABSTRACT
Purpose:
The aim of the present study was to investigate anticonvulsant effect of the ethanolic extract of the roots of Carissa carandas (ERCC) on electrically and chemically induced seizures.Methods:
The ethanolic extract of the roots of C. carandas (100, 200 and 400 mg/kg, i.p.) was studied for its anticonvulsant effect on maximal electroshock-induced seizures and pentylenetetrazole-, picrotoxin-, bicuculline- and N-methyl-dl-aspartic acid-induced seizures in mice. The latency of tonic convulsions and the number of animals protected from tonic convulsions were noted.Results:
ERCC (100-400 mg/kg) significantly reduced the duration of seizures induced by maximal electroshock (MES). However, only 200 and 400mg/kg of the extract conferred protection (25 and 50%, respectively) on the mice. The same doses also protected animals from pentylenetetrazole-induced tonic seizures and significantly delayed the onset of tonic seizures produced by picrotoxin and N-methyl-dl-aspartic acid. The extract had no effect on bicuculline-induced seizures.Conclusion:
The data suggest that the ethanolic root extract of C. carandas may produce its anticonvulsant effects via non-specific mechanisms since it reduced the duration of seizures produced by maximal electroshock as well as delayed the latency of seizures produced by pentylenetetrazole and picrotoxin
Texto completo:
DisponíveL
Índice:
AIM (África)
Assunto principal:
Convulsões
/
Apocynaceae
Idioma:
Inglês
Revista:
Trop. j. pharm. res. (Online)
Ano de publicação:
2009
Tipo de documento:
Artigo
Instituição/País de afiliação:
Department of Pharmaceutics, Soniya Education Trust's College of Pharmacy/IN
/
Department of Pharmacognosy, N. G. S. M. Institute of Pharmaceutical Sciences/IN
/
Department of Pharmacology, Srinivas College of Pharmacy/IN
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