Association of acanthosis nigricans with metabolic syndrome - An analytic cross-sectional study
An. bras. dermatol
;
98(4): 460-465, July-Aug. 2023. tab
Artigo
em Inglês
|
LILACS-Express
| LILACS
| ID: biblio-1447239
ABSTRACT
Abstract Background:
Globally, few studies have been undertaken to assess the association of acanthosis nigricans (AN) with metabolic syndrome (MS). Most of the available studies have either focused on a particular age group, gender, ethnicity or on a single component of MS.Objectives:
To determine the association between AN and MS as a whole and with all individual components of MS in adult patients of either gender. Material andmethods:
This was a cross-sectional study with a comparative group. Eighty-one subjects were recruited in each group. Fasting plasma glucose (FPG) and lipid profile were done. MS was defined by using the international diabetic federation (IDF) criteria. Association of body mass index (BMI), waist circumference, blood pressure, FPG, high-density lipoprotein (HDL) and triglycerides (TG) with AN was assessed by Pearson's chi-square test followed by univariate and multivariate analysis.Results:
The prevalence of MS was found to be significantly higher in the group with AN. On univariate analysis, a significant association of AN was found with BMI, waist circumference, high systolic and diastolic blood pressure, HDL, and TG. Multivariate analysis revealed a significant association between waist circumference, high systolic and diastolic blood pressure, and high TG levels with AN. The risk of MS was found to be eight times higher in cases of AN. Studylimitations:
The small sample size and single-center data are the limitations of the present study.Conclusion:
AN is strongly associated with MS as a whole and with its individual components including increased waist circumference, hypertension, and dyslipidemia.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Tipo de estudo:
Estudo observacional
/
Estudo de prevalência
/
Fatores de risco
Idioma:
Inglês
Revista:
An. bras. dermatol
Assunto da revista:
Dermatologia
Ano de publicação:
2023
Tipo de documento:
Artigo
País de afiliação:
Índia
Instituição/País de afiliação:
All India Institute of Medical Sciences/IN
/
Jawahar Lal Nehru Medical College/IN
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