Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: A collaborative study by GATMO-TC and INCUCAI
Hematol., Transfus. Cell Ther. (Impr.)
;
45(2): 224-234, Apr.-June 2023. tab, graf, mapas
Artigo
em Inglês
| LILACS
| ID: biblio-1448349
ABSTRACT
Special Article Introduction Hematopoietic stem cell transplantation is the only curative treatment for many disorders and international data shows a growing trend. Method We aimed to evaluate the temporal trends in HSCT transplant rates in Argentina. A time-series analysis was performed for the period 2009 to 2018 using the national database from the National Central Coordinating Institute for Ablations and Implants. Crude and standardized transplant rates were calculated. A permutation joinpoint regression model analysis was used to identify significant changes over time. Results Altogether, 8,474 transplants were reported to INCUCAI by 28 centers (autologous 67.5%); the main indication was multiple myeloma (30%). The WHO age-sex standardized HSCT rates for the entire country were 153.3 HSCT/10 million inhabitants (95% CI 141.7-165.8) in 2009 and 260.1 HSCT/10 million inhabitants (95% CI 245.5-275.5) in 2018. There was a large gap in HSCT rates among the states and regions. The transplant rate was higher for autologous transplants throughout the years. Within the allogeneic group, the related donor transplant rate was higher than the unrelated donor transplant rate. The joinpoint regression analysis of HSCT rates for the whole country over time showed an observed annual percentage change of 6.3% (95% CI 5.4-7.3; p< 0.01). No changes were observed for unrelated donors during the study period. Conclusions Age-sex standardized HSCT rates in Argentina are increasing, mainly due to autologous and family donor allogeneic transplants. A wide variation across the country was found, demonstrating differences in the access to transplantation among Argentine regions.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Transplante Autólogo
/
Transplante de Células-Tronco
Tipo de estudo:
Estudo observacional
Limite:
Humanos
País/Região como assunto:
América do Sul
/
Argentina
Idioma:
Inglês
Revista:
Hematol., Transfus. Cell Ther. (Impr.)
Assunto da revista:
Hematologia
/
TransfusÆo de Sangue
Ano de publicação:
2023
Tipo de documento:
Artigo
País de afiliação:
Argentina
Instituição/País de afiliação:
FUNDALEU/AR
/
Fundación Favaloro/AR
/
Hospital Alemán/AR
/
Hospital Italiano de Buenos Aires/AR
/
Hospital Nacional de Clínicas José de San Martín/AR
/
Hospital Privado Universitario de Córdoba/AR
/
Hospital Universitario Austral/AR
/
Instituto Alexander Fleming/AR
/
Instituto Nacional Central Único Coordinador de Ablación e Implante/AR
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