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Vascular endothelial growth factor gene insertion/deletion polymorphism is associated with Vitamin D level in Turkish patients with coronavirus disease 2019
Yigit, Serbulent; Tural, Sengul; Aci, Recai; Sezer, Ozlem.
  • Yigit, Serbulent; Ondokuz Mayis University, Faculty of Veterinary Medicine. Department of Genetics. Samsun. TR
  • Tural, Sengul; Ondokuz Mayis University, Faculty of Medicine. Department of Medical Biology. Samsun. TR
  • Aci, Recai; Samsun Training & Research Hospital. Department of Biochemistry. Samsun. TR
  • Sezer, Ozlem; Samsun Training & Research Hospital. Department of Medical Genetics. Samsun. TR
Rev. Assoc. Med. Bras. (1992, Impr.) ; 69(7): e20221713, 2023. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1449094
ABSTRACT
SUMMARY

OBJECTIVE:

Coronavirus disease 2019 emerges as a disease caused by severe acute respiratory syndrome coronavirus 2. It is a systemic disease associated with vascular inflammation and endothelial damage. In this study, we aimed to investigate whether vascular endothelial growth factor gene insertion/deletion polymorphism is associated with coronavirus disease 2019 in the Turkish population.

METHODS:

The study included 179 participants (79 patients with coronavirus disease 2019 and 100 controls). DNA isolation was made from peripheral blood, and then the polymerase chain reaction analysis was performed.

RESULTS:

When we analyze vascular endothelial growth factor gene insertion/deletion polymorphism in the study group, we found that the DD genotype and D allele were found to be statistically significantly different when compared to coronavirus disease 2019 patients with high vitamin D value (p=0.005 for DD genotype and p=0.006 for D allele) in the control group. In this high-level control group, when we analyze II+ID genotype versus DD, a statistically significant difference was also detected (p=0.007).

CONCLUSION:

As a result of the study, we found that DD genotype and D allele were associated with vitamin D level in Turkish patients with coronavirus disease 2019.


Texto completo: DisponíveL Índice: LILACS (Américas) Tipo de estudo: Fatores de risco Idioma: Inglês Revista: Rev. Assoc. Med. Bras. (1992, Impr.) Assunto da revista: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / Medicina Ano de publicação: 2023 Tipo de documento: Artigo País de afiliação: Turquia Instituição/País de afiliação: Ondokuz Mayis University, Faculty of Medicine/TR / Ondokuz Mayis University, Faculty of Veterinary Medicine/TR / Samsun Training & Research Hospital/TR

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Texto completo: DisponíveL Índice: LILACS (Américas) Tipo de estudo: Fatores de risco Idioma: Inglês Revista: Rev. Assoc. Med. Bras. (1992, Impr.) Assunto da revista: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / Medicina Ano de publicação: 2023 Tipo de documento: Artigo País de afiliação: Turquia Instituição/País de afiliação: Ondokuz Mayis University, Faculty of Medicine/TR / Ondokuz Mayis University, Faculty of Veterinary Medicine/TR / Samsun Training & Research Hospital/TR