Factors associated with low skeletal muscle index among patients with Crohn's disease
Rev. Assoc. Med. Bras. (1992, Impr.)
;
69(7): e20221606, 2023. tab
Artigo
em Inglês
|
LILACS-Express
| LILACS
| ID: biblio-1449102
ABSTRACT
SUMMARY OBJECTIVE:
Disease-related skeletal muscle loss is highly prevalent among patients with Crohn's disease. Low skeletal muscle mass lead to disability and interventions to prevent skeletal mass loss as an effective strategy to prevent disability. The aim of this article was to identify the factor associated with skeletal muscle loss of Crohn's disease and seek for management target for the prevention of sarcopenia-related disability.METHODS:
Patients with Crohn's disease were divided into low and normal skeletal muscle mass groups based on L3 skeletal muscle index using abdominal CT scans. The clinical and laboratory parameters and colonoscopy were compared between the two groups. Univariate and multivariate regression logistic models were built to identify the prognostic markers of Crohn's disease-associated muscle loss.RESULTS:
A total of 191 Crohn's disease patients were enrolled in this study, of whom 116 (60.73%) were detected to have low L3 skeletal muscle index, including 71 (68.26%) males. The multivariate logistic regression analysis showed that age (OR 1.031, 95%CI 1.006-1.057), female gender (OR 2.939, 95%CI 1.386-6.233), disease duration (OR 0.988, 95%CI 0.980-0.996), endoscopic disease activity (simple endoscopic score for Crohn's disease) (OR 0.923, 95%CI 0.855-0.996), serum albumin (OR 1.079, 95%CI 1.009-1.154), and serum creatinine (OR 1.037, 95%CI 1.011-1.063) were associated with L3 skeletal muscle index among Crohn's disease patients.CONCLUSION:
The gender, age, and duration of disease were uncontrollable factors associated with muscle loss of Crohn's disease. The treatment target of mucosal healing and improved nutritional status may be beneficial for maintaining muscle mass among Crohn's disease patients.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Tipo de estudo:
Estudo prognóstico
/
Fatores de risco
Idioma:
Inglês
Revista:
Rev. Assoc. Med. Bras. (1992, Impr.)
Assunto da revista:
EducaÆo em Sa£de
/
GestÆo do Conhecimento para a Pesquisa em Sa£de
/
Medicina
Ano de publicação:
2023
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
China
Instituição/País de afiliação:
Yangzhou University/CN
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