Can TILs be associated with prognostic factors and survival rates in breast cancer? A retrospective analysis
Mastology (Online)
;
332023. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1451125
ABSTRACT
Introduction:
The relationship between the tumor inflammatory infiltrate, also known as tumor-infiltrating lymphocytes (TILs), and invasive breast carcinomas has been extensively studied in recent years to verify its association with prognosis and response to treatment. The goal of this study was to associate the presence of TILs with patient's survival time.Methods:
We studied prognostic clinicopathological characteristics already established in the literature and their impact on overall five-year survival time of patients with invasive breast cancer treated at Hospital Santa Casa in Belo Horizonte, Minas Gerais, Brazil, in 2011 (n=290). This was an observational and retrospective study.Results:
The presence of TILs was associated with tumors of no special type (p=0.018) and with younger age of the patients (p=0.042). Smaller tumor size (HR 19.24; 95%CI 4.3086.15; p<0.001), absence of metastasis to the axillary lymph nodes (HR 2.80; 95%CI 1.027.70; p=0.002), positivity for progesterone receptor (HR 0.39; 95%CI 0.170.87; p=0.022), and presence of TILs (HR 0.23; 95%CI 0.080.65; p=0.005) were associated with longer survival times.Conclusions:
This study suggests that the presence of TILs, along with other clinicopathological characteristics, is a prognostic factor in breast cancer
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Neoplasias da Mama
/
Linfócitos do Interstício Tumoral
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Mastology (Online)
Assunto da revista:
Neoplasias da Mama
Ano de publicação:
2023
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Faculdade Santa Casa de Belo Horizonte/BR
/
Hospital Sírio-Libanês/BR
/
Universidade Federal de Minas Gerais/BR
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