CD34 immunoexpression in penile carcinoma
Acta cir. bras
;
172002.
Artigo
em Inglês
|
LILACS-Express
| LILACS, VETINDEX
| ID: biblio-1456026
ABSTRACT
OBJECTIVE:
To investigate microvessel density as a risk factor in squamous cell carcinoma of the penis.METHODS:
Fifty patients with penile carcinoma were evaluated retrospectively. The mean age and standard deviation were 60.8±11.8 years. All of them were treated by penectomy and with positive nodes underwent groin lymphadenectomy. Tumor grading was 36 G1 and 24 G2/3. Primary lesion stage was 22 pT1 and 28 pT2-4. Positive inguinal nodes were observed in 18 patients. Selected paraffin embedded sections were submitted to CD34 immunohistochemical analysis by the avidin-biotin-immunoperoxidase method with antigen retrieval. All slides were examined using an automatic analyzer system and the number of micro-vessels in 10 high magnification power fields (400X) were counted in a blind analysis.RESULTS:
Median number of microvessels was 631 in G1 versus 695 in G2/3 tumors (p=0.78), and 696 in pT1 versus 566 pT2-4 tumors (p=0.23). The respective data for pN0 patients was 525 and for pN+ was 696 (p=0.01), which is an unexpected result.CONCLUSION:
CD34 immunoexpression or microvessel density determined by this method bear no association with tumor grade, stage or prognosis.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Tipo de estudo:
Estudo prognóstico
/
Fatores de risco
Idioma:
Inglês
Revista:
Acta cir. bras
Ano de publicação:
2002
Tipo de documento:
Artigo
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