Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats
Acta cir. bras
;
29(9): 608-614, 09/2014. graf, ilus, tab
Artigo
em Inglês
| LILACS, VETINDEX
| ID: biblio-1456223
ABSTRACT
PURPOSE:
To evaluate the effects of duodenal-jejunal bypass (DJB) on serum and hepatic profiles of obese rats fed on a western diet (WD).METHODS:
Twenty eight male Wistar rats were fed a standard rodent chow diet (CTL group) or WD ad libitum. After 10 weeks, WD rats were submitted to sham (WD SHAM) or duodenal-jejunal bypass (WD DJB). Body weight, fat pad depots, glycemia, insulinemia, HOMA-IR, TyG, lipids profile and hepatic analyses were evaluated two months after surgery.RESULTS:
The WD SHAM group presented greater obesity, hyperglycemia, hyperinsulinemia, insulin resistance, hypertriglyceridemia and hepatic steatosis than the CTL group. WD DJB rats presented decreased serum glucose and insulin resistance, when compared to WD SHAM animals, without changes in insulinemia. In addition, DJB surgery normalized serum TG and attenuated TG accumulation and steatosis in the liver of the WD DJB group. Hepatic ACC and FAS protein expressions were similar in all groups.CONCLUSION:
Duodenal-jejunal bypass attenuates hepatic parameters of non-alcoholic fatty liver disease in obese rats fed on a western diet.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Derivação Gástrica
/
Hepatopatia Gordurosa não Alcoólica
/
Dieta Ocidental
/
Camundongos Obesos
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Ano de publicação:
2014
Tipo de documento:
Artigo
Instituição/País de afiliação:
Federal University of Maranhão/BR
/
State University of Western Parana (UNIOESTE)/BR
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