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Epidemiological characterization and prognostic factors in patients with confirmed cerebral cryptococcosis in central Taiwan
Chen, Chang-Hua; Sy, Hiu-Ngar; Lin, Li-Jhen; Yen, Hua-Cheg; Wang, Shao-Hung; Chen, Wei-Liang; Chen, Yu-Min; Chang, Yu-Jun.
  • Chen, Chang-Hua; Changhua Christian Hospital. Changhua. TW
  • Sy, Hiu-Ngar; Changhua Christian Hospital. Changhua. TW
  • Lin, Li-Jhen; Changhua Christian Hospital. Changhua. TW
  • Yen, Hua-Cheg; Changhua Christian Hospital. Changhua. TW
  • Wang, Shao-Hung; National Chiayi University. Chiayi City. TW
  • Chen, Wei-Liang; Changhua Christian Hospital. Changhua. TW
  • Chen, Yu-Min; Changhua Christian Hospital. Changhua. TW
  • Chang, Yu-Jun; Changhua Christian Hospital. Changhua. TW
J. venom. anim. toxins incl. trop. dis ; 21: 1-11, 31/03/2015. tab
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1484620
ABSTRACT
Background Cryptococcal meningitis is a deadly fungal infection. This study aimed to characterize the epidemiology of cerebral cryptococcosis and to define its prognostic factors. Methods This cross-sectional study collected clinical information from cryptococcal meningitis patients with confirmed cerebral cryptococcosis from 2006 to 2012 at the Changhua Christian Healthcare System to access prognostic factors. Result Fifty-nine adult cryptococcal meningitis patients were studied. The incidence at Changhua Christian Healthcare System was approximately 170 episodes per 100,000 patients within the studied period. Forty-one of 59 cryptococcal meningitis patients developed complications. Overall, 12 of 59 patients died, for a three-month mortality rate of 20.3 %. Prognostic factors positively associated with the three-month mortality included age (>55 years), patient delay, prolonged delay by the doctor in administering antifungal agent therapy, duration of intensive care unit stay, chronic lung disease, cryptococcemia, headache, altered mental status, positive blood cultures, and high cerebrospinal fluid opening pressure (>250 mm H2O). Conclusions We strongly recommend early administration of an antifungal agent to each suspected cryptococcal meningitis patient to decrease both the delay by doctors in administering therapy and the mortality risk. Aggressive and supportive care for severe cryptococcal meningitis patients is critical to decrease overall mortality from this infection.
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Taiwan / Meningite Criptocócica / Criptococose / Cryptococcus neoformans / Cryptococcus gattii Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Humanos País/Região como assunto: Ásia Idioma: Inglês Revista: J. venom. anim. toxins incl. trop. dis Ano de publicação: 2015 Tipo de documento: Artigo Instituição/País de afiliação: Changhua Christian Hospital/TW / National Chiayi University/TW

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Taiwan / Meningite Criptocócica / Criptococose / Cryptococcus neoformans / Cryptococcus gattii Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Humanos País/Região como assunto: Ásia Idioma: Inglês Revista: J. venom. anim. toxins incl. trop. dis Ano de publicação: 2015 Tipo de documento: Artigo Instituição/País de afiliação: Changhua Christian Hospital/TW / National Chiayi University/TW