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The evaluation of IgG4 and IgG expression in cutaneous Rosai-Dorfman disease
Zou, Puyu; Zhan, Yi; Xue, Ruzeng; Liu, Yu; Zhang, Guiying.
  • Zou, Puyu; Central South University. Second Xiangya Hospital. Department of Dermatology. Changsha. CN
  • Zhan, Yi; Central South University. Second Xiangya Hospital. Department of Dermatology. Changsha. CN
  • Xue, Ruzeng; Southern Medical University. Dermatology Hospital. Dermatology Department. Guangzhou. CN
  • Liu, Yu; Central South University. Second Xiangya Hospital. Department of Dermatology. Changsha. CN
  • Zhang, Guiying; Central South University. Second Xiangya Hospital. Department of Dermatology. Changsha. CN
An. bras. dermatol ; 98(5): 651-655, 2023. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1505670
ABSTRACT
Abstract Objective The authors investigated the expression of IgG4 and IgG in cutaneous Rosai-Dorfman Disease (CRDD) to further improve the understanding of this disease. Methods The authors retrospectively reviewed the clinicopathological features of 23 CRDD patients. The authors diagnosed CRDD by the presence of emperipolesis and immunohistochemical (IHC) staining of histiocytes consisting of S-100(+)/CD68(+)/CD1a(-) cells. The expressions of IgG and IgG4 in cutaneous specimens were assessed by IHC (EnVision) and quantitatively calculated by a medical image analysis system. Results All 23 patients, including 14 males and 9 females, were confirmed to have CRDD. Their ages ranged from 17 to 68 years (mean 47.91 ± 14.16). The most frequently affected skin regions were the face, followed by the trunk, ears, neck, limbs, and genitals. In 16 of these cases, the disease presented as a single lesion. IHC staining of sections showed that IgG was positive (≥ 10 cells/High-Power Field [HPF]) in 22 cases, while IgG4 was positive (≥ 10 cells/HPF) in 18 cases. Moreover, the IgG4/IgG proportion ranged from 1.7% to 85.7% (mean 29.50 ± 24.67%, median 18.4%) in the 18 cases. Study limitations In the majority of studies, as well as in the current study, the design. RDD is a rare disease, so the sample size is small. In the next studies to come, the authors will expand the sample for multi-center verification and in-depth study. Conclusion The positive rates of IgG4 and IgG and the IgG4/IgG ratio assessed through IHC staining may be important in understanding the pathogenesis of CRDD.


Texto completo: DisponíveL Índice: LILACS (Américas) Tipo de estudo: Ensaio Clínico Controlado Idioma: Inglês Revista: An. bras. dermatol Assunto da revista: Dermatologia Ano de publicação: 2023 Tipo de documento: Artigo / Documento de projeto País de afiliação: China Instituição/País de afiliação: Central South University/CN / Southern Medical University/CN

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Texto completo: DisponíveL Índice: LILACS (Américas) Tipo de estudo: Ensaio Clínico Controlado Idioma: Inglês Revista: An. bras. dermatol Assunto da revista: Dermatologia Ano de publicação: 2023 Tipo de documento: Artigo / Documento de projeto País de afiliação: China Instituição/País de afiliação: Central South University/CN / Southern Medical University/CN