Molecular aspects of the teratogenesis of rubella virus
Biol. Res
;
52: 47-47, 2019. ilus
Artigo
em Inglês
| LILACS
| ID: biblio-1505767
ABSTRACT
Rubella or German measles is an infection caused by rubella virus (RV). Infection of children and adults is usually characterized by a mild exanthematous febrile illness. However, RV is a major cause of birth defects and fetal death following infection in pregnant women. RV is a teratogen and is a major cause of public health concern as there are more than 100,000 cases of congenital rubella syndrome (CRS) estimated to occur every year. Several lines of evidence in the field of molecular biology of RV have provided deeper insights into the teratogenesis process. The damage to the growing fetus in infected mothers is multifactorial, arising from a combination of cellular damage, as well as its effect on the dividing cells. This review focuses on the findings in the molecular biology of RV, with special emphasis on the mitochondrial, cytoskeleton and the gene expression changes. Further, the review addresses in detail, the role of apoptosis in the teratogenesis process.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Complicações Infecciosas na Gravidez
/
Rubéola (Sarampo Alemão)
/
Vírus da Rubéola
/
Anormalidades Congênitas
/
Síndrome da Rubéola Congênita
/
Teratogênese
Limite:
Feminino
/
Humanos
/
Gravidez
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
Índia
Instituição/País de afiliação:
ICMR-National Institute of Virology/IN
Similares
MEDLINE
...
LILACS
LIS