Effects of Calendula officinalis extract on liver histopathology, lipid profile, and oxidative stress in rats submitted to a diet rich in cholesterol and carbohydrates
Acta cir. bras
;
38: e383723, 2023. tab, graf
Artigo
em Inglês
|
LILACS-Express
| LILACS, VETINDEX
| ID: biblio-1513546
ABSTRACT
ABSTRACT Purpose:
To evaluate the modulatory properties of Calendula officinalis L. (Asteraceae) (C. officinalis) extract on cafeteria diet-fed rats.Methods:
A cafeteria diet was administered ad libitum for 45 days to induce dyslipidemia. Then, the rats were treated with the formulations containing C. officinalis in the doses of 50, 100, and 150 mg/kg or only with the vehicle formulation; the control group received a commercial ration.Results:
The cafeteria diet decreased glutathione S-transferase activity and high-density lipoprotein plasmatic levels and damaged the hepatic architecture. The C. officinalis extract was able to reduce lipid infiltration in liver tissue and to modulate oxidative stress and lipid profile markers.Conclusions:
The correlations between the variables suggest a pathological connection between oxidative stress markers and serum lipid profile.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Idioma:
Inglês
Revista:
Acta cir. bras
Ano de publicação:
2023
Tipo de documento:
Artigo
/
Documento de projeto
Instituição/País de afiliação:
Universidade Federal de Juiz de Fora/BR
/
Universidade Federal de São Paulo/BR
/
Universidade Federal de Viçosa/BR
/
Universidade Federal do Estado do Rio de Janeiro/BR
/
Universidade Santo Amaro/BR
/
Universidade do Estado do Rio de Janeiro/BR
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