Meta-analysis to Implement Alpha-Synuclein in Extracellular Vesicles as a Potential Biomarker for Parkinson's Disease
Rev. invest. clín
;
75(4): 193-202, Jul.-Aug. 2023. tab, graf
Artigo
em Inglês
|
LILACS-Express
| LILACS
| ID: biblio-1515323
ABSTRACT
ABSTRACT Background:
In Parkinson's disease (PD), exosomes carry α-synuclein (α-syn), a fibrillar protein aggregates with potential value as a biomarker.Objective:
Evidence on blood levels of exosomal α-syn in PD patients and controls was reviewed for their consistency.Methods:
Thirty-six studies on exosomal α-syn concentrations in PD were identified in a systematic literature search and meta-analysis.Results:
Both raw and ratio-adjusted blood exosomal α-syn levels were consistently higher in PD patients than in controls. The standardized mean difference (SMD) was 1.54 (0.18-2.90, CI95%, p < 0.01) and 1.53 (0.23-2.83, CI95%, p < 0.01), respectively.Conclusion:
Our results suggest that exosomal α-syn concentrations could be a useful biomarker for PD.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Tipo de estudo:
Revisões Sistemáticas Avaliadas
Idioma:
Inglês
Revista:
Rev. invest. clín
Assunto da revista:
Medicina
Ano de publicação:
2023
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
México
Instituição/País de afiliação:
Instituto de Investigaciones Biomédicas/MX
/
Universidad Nacional Autónoma de México/MX
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