Study of long non-coding RNA Tug 1 expression in Egyptian colorectal adenocarcinoma patients
J. coloproctol. (Rio J., Impr.)
;
43(3): 166-170, July-sept. 2023. tab, graf, ilus
Artigo
em Inglês
| LILACS
| ID: biblio-1521148
ABSTRACT
Purpose:
Colorectal cancer (CRC) is one of the most fatal tumors worldwide. In Egypt, most CRC cases occur in individuals > 40 years old. TUG1 has been proved to be disrupted in different malignancies and may have a critical role in tumor progression, invasion, and metastasis. However, its role in CRC has not been adequately studied. Materials /Methods:
Quantitative real-time polymerase chain reaction (PCR) was used to evaluate the expression levels of long non-coding RNA (LncRNA) taurine upregulated gene 1 (TUG1), in nonmetastatic and metastatic CRC tissues and adjacent noncancerous tissues as control.Results:
LncRNA TUG1 expression was significantly upregulated in both nonmetastatic and metastatic CRC tissues, in comparison with the adjacent noncancerous tissue. It was found that TUG1 could have a possible prognostic role in CRC, by comparing the sensitivity and specificity of TUG1 with those of CEA and CA19-9.Conclusion:
The results of the current study suggest that the LncRNA TUG1 participates in the malignant behaviors of CRC cells. (AU)
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Adenocarcinoma
/
Reação em Cadeia da Polimerase Via Transcriptase Reversa
/
RNA Longo não Codificante
Limite:
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
J. coloproctol. (Rio J., Impr.)
Assunto da revista:
Cirurgia
/
Doenas Retais
/
Doenas do Colo
/
Gastroenterologia
/
Cirurgia
Ano de publicação:
2023
Tipo de documento:
Artigo
País de afiliação:
Egito
Instituição/País de afiliação:
Alexandria University/EG
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