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WD repeat domain 5 promotes the development of late-onset preeclampsia by activating nuclear factor kappa B
Zhao, Xudong; Su, Fengyun; Kong, Fanhua; Su, Juan; Yang, Xiaojing; Li, Lei; Li, Aihua; Li, Qinwen.
  • Zhao, Xudong; Liaocheng Peoples Hospital. Department of Obstetrics and Gynaecology. Liaocheng. CN
  • Su, Fengyun; The Second Affiliated Hospital of Shandong First Medical University. Second Affiliated Hospital. Department of Pharmacy. Taian City. CN
  • Kong, Fanhua; The Affiliated Taian City Central Hospital of Qingdao University. Taian City Central Hospital. Departments of Thoracic Surgery. Taian City. CN
  • Su, Juan; The Affiliated Taian City Central Hospital of Qingdao University. Taian City Central Hospital. Department of Obstetrics and Gynecology Color Ultrasound. Taian City. CN
  • Yang, Xiaojing; The Affiliated Taian City Central Hospital of Qingdao University. Taian City Central Hospital. Department of Obstetrics. Taian City. CN
  • Li, Lei; Shandong Provincial Hospital Affiliated to Shandong First Medical University. Shandong Provincial Hospital. Department of Obstetrics. Jinan City. CN
  • Li, Aihua; Liaocheng Peoples Hospital. Department of Obstetrics and Gynaecology. Liaocheng. CN
  • Li, Qinwen; The Affiliated Taian City Central Hospital of Qingdao University. Taian City Central Hospital. Department of Obstetrics. Taian City. CN
Acta cir. bras ; 38: e386223, 2023. tab, graf, ilus
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1527603
ABSTRACT

Purpose:

Over-activation of nuclear factor kappa B (NF-κB) was proven to be involved in the pathogenesis of preeclampsia. However, its regulation mechanism is not clear yet. This paper explored the role of WD repeat domain 5 (WDR5) in the development of late-onset preeclampsia and its relationship with NF-κB.

Methods:

WDR5 expression was detected in normal placentas and placentas from late-onset preeclampsia patients. CCK-8 and colony formation assays were conducted to appraise the proliferative ability of trophoblast. Migration and invasion were observed by wound healing and transwell assays. The interaction between WDR5 and NF-κB inhibitor I-kappa-B-alpha (IkBa) was verified by Co-immunoprecipitation analysis. Immunofluorescence was used to analyze the activation of NF-κB. Finally, we tested the role of WDR5 using the mice late-onset preeclampsia model.

Results:

WDR5 was highly expressed in the placentas of late-onset preeclampsia patients. WDR5 overexpression suppressed cell proliferation, migration, and invasion in trophoblast. WDR5 could interact with IkBa to activate NF-κB. Knockdown of NF-κB counteracted the anti-proliferative and anti-metastatic effects of WDR5 overexpression in trophoblast. In-vivo studies suggested that targeting WDR5 combated late-onset preeclampsia development.

Conclusions:

Our finding provides new insights into the role of WDR5 in late-onset preeclampsia development.
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Pré-Eclâmpsia / Trofoblastos / NF-kappa B Tipo de estudo: Estudo prognóstico Idioma: Inglês Revista: Acta cir. bras Assunto da revista: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2023 Tipo de documento: Artigo País de afiliação: China Instituição/País de afiliação: Liaocheng Peoples Hospital/CN / Shandong Provincial Hospital Affiliated to Shandong First Medical University/CN / The Affiliated Taian City Central Hospital of Qingdao University/CN / The Second Affiliated Hospital of Shandong First Medical University/CN

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Pré-Eclâmpsia / Trofoblastos / NF-kappa B Tipo de estudo: Estudo prognóstico Idioma: Inglês Revista: Acta cir. bras Assunto da revista: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2023 Tipo de documento: Artigo País de afiliação: China Instituição/País de afiliação: Liaocheng Peoples Hospital/CN / Shandong Provincial Hospital Affiliated to Shandong First Medical University/CN / The Affiliated Taian City Central Hospital of Qingdao University/CN / The Second Affiliated Hospital of Shandong First Medical University/CN