Your browser doesn't support javascript.
loading
Associations between insomnia and large vessel occlusion acute ischemic stroke: An observational study
Xu, Huali; Li, Weili; Chen, Jiahao; Zhang, Piao; Rong, Siming; Tian, Jinping; Zhang, Yuqian; Li, Yanke; Cui, Zhenzhen; Zhang, Yuhu.
  • Xu, Huali; Southern Medical University. Guangdong Provincial Peoples Hospital (Guangdong Academy of Medical Sciences). Guangdong Neuroscience Institute. Guangzhou. CN
  • Li, Weili; Capita Medical University. Xuanwu Hospital. Cerebrovascular Diseases Research Institute. Beijing. CN
  • Chen, Jiahao; Capital Medical University. Department of Neurobiology. Beijing. CN
  • Zhang, Piao; Southern Medical University. Guangdong Provincial Peoples Hospital (Guangdong Academy of Medical Sciences). Guangdong Neuroscience Institute. Guangzhou. CN
  • Rong, Siming; Southern Medical University. Guangdong Provincial Peoples Hospital (Guangdong Academy of Medical Sciences). Guangdong Neuroscience Institute. Guangzhou. CN
  • Tian, Jinping; Binzhou Medical College. Binzhou Central Hospital. Department of Information. Binzhou. CN
  • Zhang, Yuqian; Binzhou Medical College. Binzhou Centra Hospital. Department of Neurology. Binzhou. CN
  • Li, Yanke; Binzhou Medical College. Binzhou Centra Hospital. Department of Neurology. Binzhou. CN
  • Cui, Zhenzhen; Binzhou Medical College. Binzhou Centra Hospital. Department of Neurology. Binzhou. CN
  • Zhang, Yuhu; Southern Medical University. Guangdong Provincial Peoples Hospital (Guangdong Academy of Medical Sciences). Guangdong Neuroscience Institute. Guangzhou. CN
Clinics ; 78: 100297, 2023. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1528424
ABSTRACT
Abstract

Objectives:

This study explored the association between insomnia and the clinical outcome of large vessel occlusion Acute Ischemic Stroke (AIS) and attempted to explore its potential mechanisms from the perspectives of inflammation and oxidative stress.

Methods:

AIS patients who underwent endovascular treatment for large vessel occlusion at Binzhou Central Hospital from 2018 to 2022 (n = 508) were included. Patients were divided into an insomnia group and a non-insomnia group. Insomnia was judged by self-reported Athens Insomnia Scale score. Regression analysis was used to compare the differences in the 24-hour and 7-day National Institutes of Health Stroke Scale (NIHSS) score, Early Neurological Deterioration (END), early adverse event incidence, 90-day prognosis and mortality, and serum bio-markers levels.

Results:

The incidence of insomnia in the study population was 39.6% (n = 144, insomnia group; n = 364, non-insomnia group). Compared with the non-insomnia group, a worse prognosis outcome (63% vs. 49%, adjusted rate ratio 1.8, 95% Confidence Interval 1.2-3.7; p = 0.016), higher 24-h and 7-day NIHSS score (17 [9-36] vs. 13 [5-20]; p = 0.024, and 11 [4‒24) vs. 8 [2‒14]; p = 0.031, respectively), higher END (24% vs. 15%, p = 0.022), and higher incidence of adverse events were observed in the insomnia group (79% vs. 59%, p = 0.010). The 90-day mortality was higher in the insomnia group than that in the non-insomnia group (22% vs. 17%), however, such a difference was not statistically significant.

Conclusion:

Insomnia is closely related to the clinical outcome of AIS with large vessel occlusion, and inflammation and oxidative stress mechanisms may be involved.


Texto completo: DisponíveL Índice: LILACS (Américas) Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Idioma: Inglês Revista: Clinics Assunto da revista: Medicina Ano de publicação: 2023 Tipo de documento: Artigo / Documento de projeto País de afiliação: China Instituição/País de afiliação: Binzhou Medical College/CN / Capita Medical University/CN / Capital Medical University/CN / Southern Medical University/CN

Similares

MEDLINE

...
LILACS

LIS


Texto completo: DisponíveL Índice: LILACS (Américas) Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Idioma: Inglês Revista: Clinics Assunto da revista: Medicina Ano de publicação: 2023 Tipo de documento: Artigo / Documento de projeto País de afiliação: China Instituição/País de afiliação: Binzhou Medical College/CN / Capita Medical University/CN / Capital Medical University/CN / Southern Medical University/CN