Embryo development is impaired by sperm mitochondrial-derived ROS
Biol. Res
;
57: 5-5, 2024. ilus, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1550060
ABSTRACT
BACKGROUND:
Basal energetic metabolism in sperm, particularly oxidative phosphorylation, is known to condition not only their oocyte fertilising ability, but also the subsequent embryo development. While the molecular pathways underlying these events still need to be elucidated, reactive oxygen species (ROS) could have a relevant role. We, therefore, aimed to describe the mechanisms through which mitochondrial activity can influence the first stages of embryo development.RESULTS:
We first show that embryo development is tightly influenced by both intracellular ROS and mitochondrial activity. In addition, we depict that the inhibition of mitochondrial activity dramatically decreases intracellular ROS levels. Finally, we also demonstrate that the inhibition of mitochondrial respiration positively influences sperm DNA integrity, most likely because of the depletion of intracellular ROS formation.CONCLUSION:
Collectively, the data presented in this work reveals that impairment of early embryo development may result from the accumulation of sperm DNA damage caused by mitochondrial-derived ROS.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Sêmen
/
Mitocôndrias
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2024
Tipo de documento:
Artigo
País de afiliação:
Espanha
Instituição/País de afiliação:
University of Girona/ES
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