Comparative in vitro analysis of the antifungal activity of different calcium silicate-based endodontic sealers
Braz. j. oral sci
;
23: e243355, 2024. ilus
Artigo
em Inglês
| LILACS, BBO
| ID: biblio-1551649
ABSTRACT
Aim: This study aimed to perform an in vitro comparative analysis of the antifungal activity of different calcium silicate-based endodontic sealers against three fungal species. Methods: The antifungal properties of three calcium silicate-based sealers were tested: Bio-C Sealer, Cambiar a Sealer Plus BC, and MTA-Fillapex. Two commonly used sealers were used as controls: AH Plus and Endomethasone. An agar diffusion test was performed to analyze the antifungal activity of the sealers against Candida albicans, Candida glabrata, Candida tropicalis, and a mixed microbial culture medium. The results were analyzed using ANOVA (p <0.05). Results: Endomethasone exhibited the highest inhibition against all strains examined, maintaining a consistent level of inhibition throughout 7 days. MTA-Fillapex demonstrated the best performance among the calcium silicate-based sealers for the three fungal species (p < 0.05), maintaining stable values over the 7 days, surpassing that of Endomethasone. Nevertheless, MTA-Fillapex only exhibited antimicrobial effect against the mixed culture for the first 24 hours, and no antimicrobial activity was observed at 48 hours, being surpassed by all tested sealers (p < 0.05). Conclusion: Of all silicate-based sealers tested, only MTA-Fillapex exhibited promising antifungal activity. Nevertheless, care must be taken when extrapolating these results, as MTA-Fillapex exhibited poor antimicrobial activity when tested in mixed microbial cultures
Assuntos
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Materiais Restauradores do Canal Radicular
/
Cimento de Silicato
/
Bactérias
/
Candida albicans
/
Candida glabrata
/
Candida tropicalis
/
Endodontia
/
Antifúngicos
Idioma:
Inglês
Revista:
Braz. j. oral sci
Assunto da revista:
Odontologia
Ano de publicação:
2024
Tipo de documento:
Artigo
País de afiliação:
Brasil
/
Chile
Instituição/País de afiliação:
Andres Bello University/CL
/
Pontifical Catholic University of Campinas/BR
/
São Leopoldo Mandic College of Campinas/BR
/
Vale do Rio Doce University/BR
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