Protection level of anti-hepatitis B vaccine and immunoglobulin in a pediatric Cameroonian population
J. Public Health Africa (Online)
; 14(12): 1-9, 2023. figures, tables
Article
em En
| AIM
| ID: biblio-1554120
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ABSTRACT
Background:
Background:
Despite nearly twenty years of an effective vaccine, hepatitis B remains one of the most common viral infections worldwide. Mother-to-child transmission is a major route in children.Objective:
to evaluate HBV-infected mothers' children's vaccination response.Methods:
The Centre Hospitalier Dominicain St-Martin de Porres, Yaounde prenatal care (ANC) database included HBsAg-positive consenting women and their children. Social demographics were acquired using a tested questionnaire. The 5 hepatitis B indicators were evaluated and anti-HBsAg antibodies quantified by indirect ELISA. Microsoft Excel and Epi-info was used to examine data. Results. Out of 5,996 women registered, 143 were HBsAg positive (2.38% prevalence) and none were HBeAg positive. Of 143 HBsAgpositive women, 50 participated in the study. Out of 50 positive moms, 78 children were included, with a mean age ± SD of 2.33 ± 2.86 years. None of the children were infected with HBV, but all were exposed. 64 (82.05%) received anti-HBs immunoglobulin (HBIG) and a vaccine at birth, while 14 (17.95%) received only the vaccine. 72 (92.31%) children received all three vaccination doses. The vaccine responders were 62.82% (above 10 IU/mL), while 37.18% of children were nonresponders, a greater risk group if not supplemented.Conclusion:
This study found 92.31% child anti-HBV immunization coverage. WHO recommends 95% protection, but 62.82% is below that. The causes of this poor protection should be examined.Palavras-chave
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Índice:
AIM
Assunto principal:
Hepatite B
Idioma:
En
Revista:
J. Public Health Africa (Online)
Ano de publicação:
2023
Tipo de documento:
Article