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Histomorphometric comparison of two different preclinical models to evaluate the bone repair in grafted areas
Lima, Julia Raulino; Soares, Priscilla Barbosa Ferreira; Pereira, Lucas de Sousa Goulart; Perdomo, Leidys Rodríguez; Pigossi, Suzane Cristina; Oliveira, Guilherme José Pimentel Lopes de.
  • Lima, Julia Raulino; Federal University of Uberlândia. School of Dentistry. Department of Periodontology. Uberlândia. BR
  • Soares, Priscilla Barbosa Ferreira; Federal University of Uberlândia. School of Dentistry. Department of Periodontology. Uberlândia. BR
  • Pereira, Lucas de Sousa Goulart; Federal University of Uberlândia. School of Dentistry. Department of Periodontology. Uberlândia. BR
  • Perdomo, Leidys Rodríguez; Federal University of Uberlândia. School of Dentistry. Department of Periodontology. Uberlândia. BR
  • Pigossi, Suzane Cristina; Federal University of Uberlândia. School of Dentistry. Department of Periodontology. Uberlândia. BR
  • Oliveira, Guilherme José Pimentel Lopes de; Federal University of Uberlândia. School of Dentistry. Department of Periodontology. Uberlândia. BR
Braz. j. oral sci ; 23: e243937, 2024. ilus
Artigo em Inglês | LILACS, BBO | ID: biblio-1555183
ABSTRACT

Aim:

This study was performed to compare two different rat defect models (critical calvaria defects versus guided bone regeneration in the mandibular ramus) used to evaluate bone repair in grafted areas.

Methods:

A total of 12 rats were allocated in two groups according the experimental model used to evaluate the bone repair in grafted areas a critical sized-calvaria defect of 5 mm filled with bone graft (n=6) and a mandibular ramus filled with the bone graft associated with a Teflon dome-shaped membrane (n=6). Both groups were grafted with deproteinized bovine bone graft. After 60 days, the animals were euthanized and the samples obtained were submitted to histomorphometry analysis to evaluate the relative amount of bone, remaining bone substitute, and soft tissue within the grafted areas.

Results:

No differences were observed between the preclinical models evaluated in relation to the amount of bone tissue formation (19.93 ± 4.55% in calvaria vs. 21.00 ± 8.20% in mandible). However, there was a smaller amount of soft tissue (43.20 ± 10.97% vs. 57.79 ± 7.61 %; p<0.01) and a greater amount of bone substitute remaining (35.80 ± 5.52% vs. 22.28 ± 4.36 %; p<0.05) in the grafted areas in the mandible compared to calvaria defect.

Conclusion:

Preclinical models for the analysis of bone repair in grafted areas in the mandible and critical sized-calvaria defects showed different responses in relation to the amount of soft tissue and bone substitute remnants

Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Regeneração Óssea / Substitutos Ósseos / Experimentação Animal / Histologia Limite: Animais Idioma: Inglês Revista: Braz. j. oral sci Assunto da revista: Odontologia Ano de publicação: 2024 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Federal University of Uberlândia/BR

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Regeneração Óssea / Substitutos Ósseos / Experimentação Animal / Histologia Limite: Animais Idioma: Inglês Revista: Braz. j. oral sci Assunto da revista: Odontologia Ano de publicação: 2024 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Federal University of Uberlândia/BR