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Protective effect of coenzyme Q10 in cyclophosphamide-induced kidney damage in rats
Kara, Ozlem.
  • Kara, Ozlem; Kirsehir Ahi Evran University. School of Medicine. Department of Histology and Embryology. Kırşehir. TR
Rev. Assoc. Med. Bras. (1992, Impr.) ; 70(4): e20230990, 2024. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1558882
ABSTRACT
SUMMARY

OBJECTIVE:

We aimed to investigate the effect of coenzyme q10 on cyclophosphamide-induced kidney damage in rats.

METHODS:

A total of 30 female Wistar-Albino rats were utilized to form three groups. In group 1 (control group) (n=10), no drugs were given. In group 2 (cyclophosphamide group) (n=10), 30 mg/kg intraperitoneal cyclophosphamide was administered for 7 days. In group 3 (cyclophosphamide+coenzyme q10 group) (n=10), 30 mg/kg cyclophosphamide and 10 mg/kg coenzyme q10 were given for 7 days via intraperitoneal route. Right kidneys were removed in all groups. Blood malondialdehyde levels and activities of catalase and superoxide dismutase were measured. Histopathological damage was evaluated by examining the slides prepared from kidney tissue using a light microscope.

RESULTS:

Tissue damage was significantly higher in the cyclophosphamide group than in the cyclophosphamide+coenzyme q10 group (p<0.05). The malondialdehyde levels were significantly higher and the activities of superoxide dismutase and catalase were lower in the cyclophosphamide group than in the cyclophosphamide+coenzyme q10 group (p<0.05).

CONCLUSION:

Coenzyme q10 may be a good option to prevent cyclophosphamide-induced kidney damage.


Texto completo: DisponíveL Índice: LILACS (Américas) Idioma: Inglês Revista: Rev. Assoc. Med. Bras. (1992, Impr.) Assunto da revista: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / Medicina Ano de publicação: 2024 Tipo de documento: Artigo País de afiliação: Turquia Instituição/País de afiliação: Kirsehir Ahi Evran University/TR

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Texto completo: DisponíveL Índice: LILACS (Américas) Idioma: Inglês Revista: Rev. Assoc. Med. Bras. (1992, Impr.) Assunto da revista: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / Medicina Ano de publicação: 2024 Tipo de documento: Artigo País de afiliação: Turquia Instituição/País de afiliação: Kirsehir Ahi Evran University/TR