Genetic variants in miR-146a and miR-196a2 in endometriosis: a Brazilian study
Rev. Assoc. Med. Bras. (1992, Impr.)
;
70(5): e20231382, 2024. tab
Artigo
em Inglês
|
LILACS-Express
| LILACS
| ID: biblio-1558927
ABSTRACT
SUMMARY OBJECTIVE:
The aim of this study was to determine the allelic and genotypic frequencies of the polymorphisms, rs2910164 miR-146a and rs11614913 miR-196a2, by investigating their association with endometriosis.METHODS:
This is a case-control study performed with approximately 120 women. The polymorphisms were determined by real-time polymerase chain reaction. For the statistical analysis, the chi-square and logistic regression tests were used.RESULTS:
There were no significant differences in the genotype and allele frequencies of rs2910164 and rs11614913 between cases and controls. The frequencies in both polymorphisms are in accordance with Hardy-Weinberg equilibrium regarding miR-146a (patients χ2=1.64, p=0.20; controls χ2=0.25, p=0.62) and miR-196a2 (patients χ2=0.58, p=0.44; controls χ2=2.78, p=0.10). No relationship was observed between rs2910164 and rs11614913 and endometriosis in the inheritance models analyzed.CONCLUSION:
In this study, our results show that the studied polymorphisms are not implicated in the development of endometriosis.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Rev. Assoc. Med. Bras. (1992, Impr.)
Assunto da revista:
EducaÆo em Sa£de
/
GestÆo do Conhecimento para a Pesquisa em Sa£de
/
Medicina
Ano de publicação:
2024
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal do Triângulo Mineiro/BR
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