FNDC5/Irisin in dementia and cognitive impairment: update and novel perspective
Braz. j. med. biol. res
;
57: e13447, fev.2024. graf
Artigo
em Inglês
|
LILACS-Express
| LILACS
| ID: biblio-1564157
ABSTRACT
Epidemiological surveys show that the incidence of age-related dementia and cognitive impairment is increasing and it has been a heavy burden for society, families, and healthcare systems, making the preservation of cognitive function in an increasingly aging population a major challenge. Exercise is beneficial for brain health, and FDNC5/irisin, a new exercise-induced myokine, is thought to be a beneficial mediator to cognitive function and plays an important role in the crosstalk between skeletal muscle and brain. This review provides a critical assessment of the recent progress in both fundamental and clinical research of FDNC5/irisin in dementia and cognitive impairment-related disorders. Furthermore, we present a novel perspective on the therapeutic effectiveness of FDNC5/irisin in alleviating these conditions.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
2024
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
China
Instituição/País de afiliação:
Taian City Central Hospital/CN
/
The Second School of Clinical Medicine of Binzhou Medical University/CN
/
Weihai Municipal Hospital affiliated to Shandong University/CN
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