Histological variability and the importance of clinicopathological correlation in cutaneous Rosai-Dorfman disease
An. bras. dermatol
;
91(5): 634-637, Sept.-Oct. 2016. graf
Artigo
em Inglês
| LILACS
| ID: biblio-827744
ABSTRACT
Abstract Rosai-Dorfman disease is a benign histiocytic proliferative disorder of unknown etiology. The disease mainly affects lymph node tissue, although it is rarely confined to the skin. Here, we describe a 53-year-old woman with purely cutaneous Rosai-Dorfman disease. The patient presented with a large pigmented plaque on her left leg, and sparse erythematous papules on her face and arms. A complete clinical response was achieved with thalidomide, followed by recurrence at the initial site one year later. The histological examination displayed the typical features of Rosai-Dorfman disease in the recent lesions but not in the older lesions. In the setting of no lymphadenopathy, the histopathological features of Rosai-Dorfman disease are commonly misinterpreted. Therefore, awareness of the histological aspects present at different stages, not always featuring the hallmark microscopic signs of Rosai-Dorfman disease, is particularly important for a correct diagnosis of this rare disorder.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Dermatopatias
/
Histiocitose Sinusal
Tipo de estudo:
Estudo diagnóstico
Limite:
Adolescente
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
An. bras. dermatol
Assunto da revista:
Dermatologia
Ano de publicação:
2016
Tipo de documento:
Artigo
País de afiliação:
Portugal
Instituição/País de afiliação:
Coimbra University Hospital/PT
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