Your browser doesn't support javascript.
loading
Detecting alterations of glucose and lipid components in human serum by near-infrared Raman spectroscopy
Borges, Rita de Cássia Fernandes; Navarro, Ricardo Scarparo; Giana, Hector Enrique; Tavares, Fernanda Grubisich; Fernandes, Adriana Barrinha; Silveira Junior, Landulfo.
  • Borges, Rita de Cássia Fernandes; Universidade Camilo Castelo Branco. Biomedical Engineering Institute. São José dos Campos. BR
  • Navarro, Ricardo Scarparo; Universidade Camilo Castelo Branco. Biomedical Engineering Institute. São José dos Campos. BR
  • Giana, Hector Enrique; Universidade Camilo Castelo Branco. Biomedical Engineering Institute. São José dos Campos. BR
  • Tavares, Fernanda Grubisich; Universidade Camilo Castelo Branco. Biomedical Engineering Institute. São José dos Campos. BR
  • Fernandes, Adriana Barrinha; Universidade Camilo Castelo Branco. Biomedical Engineering Institute. São José dos Campos. BR
  • Silveira Junior, Landulfo; Universidade Camilo Castelo Branco. Biomedical Engineering Institute. São José dos Campos. BR
Res. Biomed. Eng. (Online) ; 31(2): 160-168, Apr-Jun/2015. tab, graf
Artigo em Inglês | LILACS | ID: biblio-829424
ABSTRACT
Introduction Raman spectroscopy may become a tool for the analysis of glucose and triglycerides in human serum in real time. This study aimed to detect spectral differences in lipid and glucose components of human serum, thus evaluating the feasibility of Raman spectroscopy for diagnostic purposes. Methods A total of 44 samples of blood serum were collected from volunteers and submitted for clinical blood biochemical analysis. The concentrations of glucose, cholesterol, triglycerides, and low-density and high-density lipoproteins (LDL and HDL) were obtained using standard biochemical assays. Serum samples were placed in Eppendorf tubes (200 µL), kept cooled (5 °C) and analyzed with near-infrared Raman spectroscopy (830 nm, 250 mW, 50 s accumulation). The mean spectra of serum with normal or altered concentrations of each parameter were compared to determine which Raman bands were related to the differences between these two groups. Results Differences in peak intensities of altered sera compared to normal ones depended on the parameter under

analysis:

for glucose, peaks were related to glucose; for lipid compounds the main changes occurred in the peaks related to cholesterol, lipids (mainly triolein) and proteins. Principal Components Analysis discriminated altered glucose, cholesterol and triglycerides from the normal serum based on the differences in the concentration of these compounds. Conclusion Differences in the peak intensities of selected Raman bands could be seen in normal and altered blood serum samples, and may be employed as a means of diagnosis in clinical analysis.


Texto completo: DisponíveL Índice: LILACS (Américas) Idioma: Inglês Revista: Res. Biomed. Eng. (Online) Assunto da revista: Engenharia Biom‚dica Ano de publicação: 2015 Tipo de documento: Artigo / Documento de projeto País de afiliação: Brasil Instituição/País de afiliação: Universidade Camilo Castelo Branco/BR

Similares

MEDLINE

...
LILACS

LIS


Texto completo: DisponíveL Índice: LILACS (Américas) Idioma: Inglês Revista: Res. Biomed. Eng. (Online) Assunto da revista: Engenharia Biom‚dica Ano de publicação: 2015 Tipo de documento: Artigo / Documento de projeto País de afiliação: Brasil Instituição/País de afiliação: Universidade Camilo Castelo Branco/BR