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Allium sativum compared to cilostazol as an inhibitor of myointimal hyperplasia
Lima, Paulo Roberto da Silva; Bandeira, Francisco Chavier Vieira; Rolim, Janio Cipriano; Nogueira, Manuel Ricardo Sena; Pordeus, Mizael Armando Abrantes; Oliveira, Andressa Feitosa Bezerra de; Pitta, Guilherme Benjamin Brandão.
  • Lima, Paulo Roberto da Silva; Federal University of Alagoas. Maceió. BR
  • Bandeira, Francisco Chavier Vieira; Federal University of Alagoas. Maceió. BR
  • Rolim, Janio Cipriano; Federal University of Alagoas. Maceió. BR
  • Nogueira, Manuel Ricardo Sena; Federal University of Alagoas. Maceió. BR
  • Pordeus, Mizael Armando Abrantes; Federal University of Alagoas. Maceió. BR
  • Oliveira, Andressa Feitosa Bezerra de; Federal University of Alagoas. Maceió. BR
  • Pitta, Guilherme Benjamin Brandão; Federal University of Alagoas. Maceió. BR
Rev. bras. cir. cardiovasc ; 31(4): 291-299, July-Sept. 2016. tab, graf
Artigo em Inglês | LILACS | ID: biblio-829740
ABSTRACT
Abstract

Objective:

Intimal hyperplasia is associated with graft failure and vascular sutures in the first year after surgery and in postangioplasty restenosis. Allium sativum (common garlic) lowers cholesterol and has antioxidant effects; it also has antiplatelet and antitumor properties and, therefore, has great potential to reduce or inhibit intimal hyperplasia of the arteries. Our objective is to determine if the garlic has an efficacy to inhibit myointimal hyperplasia compared to cilostazol.

Methods:

Female New Zealand rabbits were divided into the following groups (n=10 each) according to treatment group A, garlic, 800 µg×kg-1×day-1, orally; group C, cilostazol, 50 mg.day-1, orally; group PS, 10 ml of 0.9% physiological saline solution, orally. Our primary is the difference of the mean of myointimal hyperplasia. Statistical analysis was performed by using ANOVA and Tukey tests, as well as the Chi-square test. We calculated the 95% confidence interval for each point estimate, and the P value was set as < 0.05.

Results:

Group PS had a mean hyperplasia rate of 35.74% (95% CI, 31.76–39.71%); group C, 16.21% (95% CI, 13.36–19.05%); and group A, 21.12% (95% CI, 17.26–25.01%); P<0.0001.

Conclusion:

We conclude that Allium sativum had the same efficacy in inhibiting myointimal hyperplasia when compared to the positive control, cilostazol.
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Arteriosclerose / Tetrazóis / Túnica Íntima / Alho Limite: Animais Idioma: Inglês Revista: Rev. bras. cir. cardiovasc Assunto da revista: Cardiologia / Cirurgia Geral Ano de publicação: 2016 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Federal University of Alagoas/BR

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Arteriosclerose / Tetrazóis / Túnica Íntima / Alho Limite: Animais Idioma: Inglês Revista: Rev. bras. cir. cardiovasc Assunto da revista: Cardiologia / Cirurgia Geral Ano de publicação: 2016 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Federal University of Alagoas/BR