Expression of TIMP-2 in HPV-16 infected oral squamous cell carcinoma in patients in Iraq
Braz. j. oral sci
; 15(1): 51-56, Jan.-Mar. 2016. ilus, tab
Article
em En
| LILACS, BBO
| ID: biblio-831002
Biblioteca responsável:
BR218.1
ABSTRACT
Aim:
To determine the expression of tissue inhibitors of metalloproteinases (TIMP-2) in oralsquamous cell carcinoma (OSCC) and the difference in its expression level between positiveand negative HPV-16 (human papilloma virus- 16) OSCC patients.Methods:
This study wasconducted on 33 biopsies obtained from patients with OSCC and 10 normal oral mucosa ascontrols. In situ hybridization (ISH) was used to investigate the presence of HPV-16, whileimmunohistochemistry (IHC) was used to estimate the expression level of TIMP-2.Results:
TheTIMP-2 was expressed in 27 (81.8%) of OSCC sections with no significant difference betweenits expression level in HPV-16 positive and HPV-16 negative OSCC cases (p=0.058). TIMP-2was found to be highly expressed in OSCC sections, and the presence of HPV was not relatedto its overexpression.Conclusions:
The percentage of samples that appeared to accommodatedetectable HPV-16 was high, but no significant difference was observed in relation to TIMP-2expression level. Future studies with a larger number of patients are highly recommended toaddress the possible association between TIMp-2 and OSCC positive HPV-16.Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Neoplasias Bucais
/
Carcinoma de Células Escamosas
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Braz. j. oral sci
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2016
Tipo de documento:
Article