Primary myelofibrosis: current therapeutic options
Rev. bras. hematol. hemoter
;
38(3): 257-263, 2016. tabela, figura
Artigo
em Inglês
| LILACS
| ID: biblio-837123
ABSTRACT
Primary myelofibrosis is a Philadelphia-negative myeloproliferative neoplasm characterized by clonal myeloid expansion, followed by progressive fibrous connective tissue deposition in the bone marrow, resulting in bone marrow failure. Clonal evolution can also occur, with an increased risk of transformation to acute myeloid leukemia. In addition, disabling constitutional symptoms secondary to the high circulating levels of proinflammatory cytokines and hepatosplenomegaly frequently impair quality of life. Herein the main current treatment options for primary myelofibrosis patients are discussed, contemplating disease-modifying therapeutics in addition to palliative measures, in an individualized patient-based approach:
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Janus Quinase 2
/
Mielofibrose Primária
/
Transtornos Mieloproliferativos
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. bras. hematol. hemoter
Assunto da revista:
Hematologia
Ano de publicação:
2016
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Estadual de Campinas/BR
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