Short-term buserelin administration induces apoptosis and morphological changes in adult rat testes
Acta cir. bras
;
32(2): 140-147, Feb. 2017. graf
Artigo
em Inglês
| LILACS
| ID: biblio-837680
ABSTRACT
Abstract Purpose: To investigate the effect of buserelin on gonadal structure and function in adult male rats. Methods: Twenty-four adult Wistar male rats were divided into three groups: two treated groups and controls. The first and second treated groups received 300 (low dose) and 500 (high dose) µg/kg buserelin, respectively, and the control group received normal saline. All groups were treated subcutaneously for five days. Results: The seminiferous tubular epithelial thickness was significant decreased in the treated groups compared with those in the control. There was a significant increase in apoptotic cell death in high dose treated group compared with low dose treated and control groups. No significant difference in serum testosterone level was observed after one month in the three groups. Conclusion: Buserelin induces apoptotic cell death and decreased diameter and epithelium thickness of seminiferous tubules in the adult rat testes.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Túbulos Seminíferos
/
Busserrelina
/
Apoptose
/
Fármacos para a Fertilidade Masculina
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2017
Tipo de documento:
Artigo
País de afiliação:
Irã
Instituição/País de afiliação:
Urmia University of Medical Sciences/IR
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